Pediatric Oncology and Hematology "Lalla Seràgnoli", Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Unit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.
Int J Mol Sci. 2021 Jan 26;22(3):1197. doi: 10.3390/ijms22031197.
The gut microbiome has emerged as a major character in the context of hematopoietic stem cell transplantation. The biology underpinning this relationship is still to be defined. Recently, mounting evidence has suggested a role for microbiome-derived metabolites in mediating crosstalk between intestinal microbial communities and the host. Some of these metabolites, such as fiber-derived short-chain fatty acids or amino acid-derived compounds, were found to have a role also in the transplant setting. New interesting data have been published on this topic, posing a new intriguing perspective on comprehension and treatment. This review provides an updated comprehensive overview of the available evidence in the field of gut microbiome-derived metabolites and hematopoietic stem cell transplantation.
肠道微生物组已成为造血干细胞移植背景下的一个主要特征。支撑这种关系的生物学基础仍有待确定。最近，越来越多的证据表明，微生物组衍生代谢物在介导肠道微生物群落与宿主之间的串扰中发挥作用。其中一些代谢物，如纤维衍生的短链脂肪酸或氨基酸衍生的化合物，在移植环境中也具有作用。关于这个主题已经发表了一些新的有趣数据，为理解和治疗提供了一个新的有趣视角。这篇综述提供了关于肠道微生物组衍生代谢物和造血干细胞移植领域现有证据的最新全面概述。
