The University of Texas MD Anderson Cancer Center.
Blood. 2020 Jul 23;136(4):383-385. doi: 10.1182/blood.2020006104.
In this issue of , Wu and colleagues report that trimethylamine -oxide (TMAO), an intestinal microbiome-dependent metabolite, worsens graft-versus-host disease (GVHD). They further found that TMAO induces M1 polarization of bone marrow–derived macrophages via the nucleotide-binding oligomerization domain–like receptor protein 3 (NLRP3). TMAO is produced by hepatic processing of intestinal bacteria–derived trimethylamine (TMA) following metabolism of certain dietary nutrients, including choline, lecithin, lcarnitine, and γ-butyrobetaine.
在本期的 中，Wu 及其同事报告称，三甲基胺氧化物（trimethylamine -oxide，TMAO）是一种肠道微生物组依赖性代谢物，可使移植物抗宿主病（graft-versus-host disease，GVHD）恶化。他们进一步发现，TMAO 通过核苷酸结合寡聚化结构域样受体蛋白 3（NLRP3）诱导骨髓来源的巨噬细胞向 M1 极化。TMAO 是由肠道细菌衍生的三甲基胺（trimethylamine，TMA）在某些膳食营养素（包括胆碱、卵磷脂、左旋肉碱和 γ-丁酸甜菜碱）代谢后，在肝脏中加工生成的。
