School of Public Health, University of Ghana, Legon, Accra, Ghana.
Cape Coast Metropolitan Health Directorate, Cape Coast, Ghana.
BMC Pregnancy Childbirth. 2021 Feb 2;21(1):105. doi: 10.1186/s12884-021-03582-2.
Malaria infection during pregnancy is of public health importance as it poses risk to the pregnant woman, her foetus and the newborn child. Intermittent preventive treatment during pregnancy using sulphadoxine-pyrimethamine is one way of reducing the effect of the disease on pregnancy outcomes. The study determined factors associated with uptake of sulphadoxine-pyrimethamine during pregnancy in the Cape Coast Metropolis of Ghana.
A health facility-based cross-sectional study involving pregnant women of ≥36 weeks gestation visiting antenatal clinics in three selected health facilities in the Cape Coast Metropolis was conducted. Participants were consecutively recruited using a structured questionnaire over a 6-week period from May to June, 2018. Descriptive statistics was used to summarize the data whilst Pearson's chi-square/Fisher exact test was performed to determine associations and logistic regression done to determine the strength of the associations.
A total of 212 pregnant women participated in the study. Formal education, initiating ANC early, taking first dose of SP during second trimester, not experiencing side effects of SP, having knowledge about schedule for taking SP and making ≥4 ANC visits were factors associated with uptake of ≥3 doses of IPTp-SP. Logistic regression analysis revealed that, mothers who made ≥4 ANC visits were 53.77 times more likely to take ≥3 doses of SP compared with those who made < 4 ANC visits (p < 0.001). Those who initiated ANC during the first trimester were 3.60 times more likely to receive ≥5 doses compared with those who initiated ANC during the second or third trimester (p = 0.022). Making ≥8 ANC visits did not increase the chances of taking ≥5 doses of SP.
Health promotion programmes targeting mothers with no formal education could increase their awareness about the importance of ANC services including uptake of IPTp-SP.
孕妇疟疾感染具有公共卫生重要性，因为它会对孕妇、胎儿和新生儿造成风险。在怀孕期间使用磺胺多辛-乙胺嘧啶进行间歇性预防治疗是减少疾病对妊娠结局影响的一种方法。本研究旨在确定加纳开普敦都会区孕妇服用磺胺多辛-乙胺嘧啶的相关因素。
这是一项基于卫生机构的横断面研究，涉及在开普敦都会区的三个选定卫生机构的产前诊所就诊的≥36 周妊娠的孕妇。在 2018 年 5 月至 6 月的 6 周内，使用结构化问卷连续招募参与者。使用描述性统计来总结数据，同时使用 Pearson 卡方/Fisher 精确检验来确定关联，使用逻辑回归来确定关联的强度。
共有 212 名孕妇参与了这项研究。正规教育、早期开始 ANC、在孕中期服用第一剂 SP、未出现 SP 副作用、了解 SP 服用时间表和进行≥4 次 ANC 就诊与服用≥3 剂 IPTp-SP 相关。逻辑回归分析显示，与进行<4 次 ANC 就诊的孕妇相比，进行≥4 次 ANC 就诊的孕妇更有可能服用≥3 剂 SP，差异有统计学意义（p<0.001）。与在孕二或孕三期开始 ANC 的孕妇相比，在孕一期开始 ANC 的孕妇更有可能接受≥5 剂的 SP，差异有统计学意义（p=0.022）。进行≥8 次 ANC 就诊并不会增加服用≥5 剂 SP 的几率。
针对没有接受正规教育的母亲的健康促进计划可以提高她们对 ANC 服务的认识，包括对 IPTp-SP 的接受程度。
