Department of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.
Department of Sport Science and Physical Education, University of Agder, 4604, Kristiansand, Norway.
BMC Res Notes. 2021 Feb 2;14(1):43. doi: 10.1186/s13104-021-05463-5.
In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cys + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cys + SFA, n = 7). The objective was to describe the short-term responses in oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cys + PUFA diet vs. Met/Cys + SFA.
The diet groups consisted of five women and two men, aged 20-38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively in the Met/Cys + PUFA group. In the Met/Cys + SFA group, median pre- and post-OGTT glucose concentrations were 4.8 mmol/L and 4.65 mmol/L after the 7-d intervention. The responses in the amino acid profiles were similar in both groups during the intervention with the exception of serine. Fatty acids decreased from baseline to day 7 in both groups. Plasma lactate and pyruvate were similar for both groups with an increase to day 3 before approaching baseline values at day 7.
ClinicalTrials.gov: NCT02647970, registration date: January 6 2016.
在这项为期 7 天的初步研究中，我们将健康、体重正常的男性和女性随机分为富含多不饱和脂肪酸的蛋氨酸和半胱氨酸限制饮食干预组（Met/Cys+PUFA，n=7）或蛋氨酸、半胱氨酸和 SFA 含量高的饮食干预组（Met/Cys+SFA，n=7）。目的是描述在摄入富含多不饱和脂肪酸的蛋氨酸/半胱氨酸饮食与富含蛋氨酸/半胱氨酸和 SFA 的饮食后，口服葡萄糖耐量、氨基酸谱、总脂肪酸谱、丙酮酸和乳酸的短期反应。
两组饮食均包括 5 名女性和 2 名男性，年龄在 20-38 岁之间。在 7 天干预后，Met/Cys+PUFA 组口服葡萄糖耐量试验（OGTT）前后的中位数血糖浓度分别为 5mmol/L 和 4mmol/L。在 Met/Cys+SFA 组，7 天干预后，OGTT 前后的中位数血糖浓度分别为 4.8mmol/L 和 4.65mmol/L。在干预期间，两组的氨基酸谱反应相似，除了丝氨酸。两组的脂肪酸均从基线下降到第 7 天。两组的血浆乳酸和丙酮酸在第 3 天升高，然后在第 7 天接近基线值。
ClinicalTrials.gov：NCT02647970，注册日期：2016 年 1 月 6 日。
