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1
Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.Gas6/TAM系统作为疾病标志物和潜在药物靶点的作用。
Dis Markers. 2021 Jan 13;2021:2854925. doi: 10.1155/2021/2854925. eCollection 2021.
2
Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.酪氨酸蛋白激酶受体 TAM 家族缺失的小鼠发生骨髓水肿，这是类风湿关节炎的早期病理标志物。
PLoS One. 2018 Oct 18;13(10):e0205902. doi: 10.1371/journal.pone.0205902. eCollection 2018.
3
Gas6/TAM Signaling Components as Novel Biomarkers of Liver Fibrosis.Gas6/TAM 信号转导组件作为肝纤维化的新型生物标志物。
Dis Markers. 2019 Sep 8;2019:2304931. doi: 10.1155/2019/2304931. eCollection 2019.
4
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target.GAS6/TAM 在非酒精性脂肪性肝炎进展中的功能作用提示 AXL 可作为治疗靶点。
Cell Mol Gastroenterol Hepatol. 2020;9(3):349-368. doi: 10.1016/j.jcmgh.2019.10.010. Epub 2019 Nov 2.
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The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome.酪氨酸激酶3/艾克受体/巨噬细胞表皮生长因子受体信号传导与原发性干燥综合征患者炎症反应、疾病活动的关联。
Joint Bone Spine. 2015 Jul;82(4):258-63. doi: 10.1016/j.jbspin.2015.01.008. Epub 2015 Apr 13.
6
TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus.狼疮中 TAM 受体配体：蛋白 S 而非 Gas6 水平反映系统性红斑狼疮的疾病活动度。
Arthritis Res Ther. 2010;12(4):R146. doi: 10.1186/ar3088. Epub 2010 Jul 16.
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Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis.靶向抑制 Axl 受体酪氨酸激酶可改善抗肾小球基底膜诱导的狼疮样肾炎。
J Autoimmun. 2018 Sep;93:37-44. doi: 10.1016/j.jaut.2018.06.001. Epub 2018 Jun 9.
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New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis.对 Tyrp3、Axl 和 Mer 受体在类风湿关节炎中作用的新认识。
Dis Markers. 2020 Jan 19;2020:1614627. doi: 10.1155/2020/1614627. eCollection 2020.
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Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE.ADAM金属蛋白酶对Axl受体酪氨酸激酶的切割增强可能导致系统性红斑狼疮的疾病发病机制。
Clin Immunol. 2016 Aug;169:58-68. doi: 10.1016/j.clim.2016.05.011. Epub 2016 May 27.
10
Role of Gas6 and TAM Receptors in the Identification of Cardiopulmonary Involvement in Systemic Sclerosis and Scleroderma Spectrum Disorders.Gas6 和 TAM 受体在系统性硬化症和硬皮病谱系疾病心肺受累识别中的作用。
Dis Markers. 2020 May 12;2020:2696173. doi: 10.1155/2020/2696173. eCollection 2020.

引用本文的文献

1
Efferocytosis by macrophages in physiological and pathological conditions: regulatory pathways and molecular mechanisms.巨噬细胞在生理和病理条件下的噬菌作用：调节途径和分子机制。
Front Immunol. 2024 May 8;15:1275203. doi: 10.3389/fimmu.2024.1275203. eCollection 2024.
2
Inhibition of Mertk Signaling Enhances Bone Healing after Tooth Extraction.抑制 Mertk 信号可增强拔牙后的骨愈合。
J Dent Res. 2023 Sep;102(10):1131-1140. doi: 10.1177/00220345231177996. Epub 2023 Jun 22.
3
Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors.Gas6 和 sAxl 血浆水平降低与 COVID-19 幸存者的脱发有关。
Int J Mol Sci. 2023 Mar 26;24(7):6257. doi: 10.3390/ijms24076257.
4
Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance.己酮可可碱通过上调 Mertk 介导的髓鞘清除来减轻缺血性白质损伤。
J Neuroinflammation. 2022 May 31;19(1):128. doi: 10.1186/s12974-022-02480-4.
5
STAT1/SOCS1/3 Are Involved in the Inflammation-Regulating Effect of GAS6/AXL in Periodontal Ligament Cells Induced by Lipopolysaccharide .STAT1/SOCS1/3 参与了 GAS6/AXL 在脂多糖诱导的牙周膜细胞炎症调节中的作用。
J Immunol Res. 2021 Oct 25;2021:9577695. doi: 10.1155/2021/9577695. eCollection 2021.

本文引用的文献

1
Gas6/TAM System: A Key Modulator of the Interplay between Inflammation and Fibrosis.Gas6/TAM 系统：炎症与纤维化相互作用的关键调节因子。
Int J Mol Sci. 2019 Oct 12;20(20):5070. doi: 10.3390/ijms20205070.
2
Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma.多受体酪氨酸激酶的综合分析确定 Axl 为肝细胞癌索拉非尼耐药的治疗靶点和介质。
Br J Cancer. 2019 Mar;120(5):512-521. doi: 10.1038/s41416-018-0373-6. Epub 2019 Feb 15.
3
A high Gas6 level in plasma predicts venous thromboembolism recurrence, major bleeding and mortality in the elderly: a prospective multicenter cohort study.血浆中高 Gas6 水平可预测老年静脉血栓栓塞复发、大出血和死亡：一项前瞻性多中心队列研究。
J Thromb Haemost. 2019 Feb;17(2):306-318. doi: 10.1111/jth.14365.
4
Candidate Biomarkers of Liver Fibrosis: A Concise, Pathophysiology-oriented Review.肝纤维化的候选生物标志物：一篇简明的、以病理生理学为导向的综述。
J Clin Transl Hepatol. 2018 Sep 28;6(3):317-325. doi: 10.14218/JCTH.2018.00006. Epub 2018 Jul 2.
5
Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis.靶向 TAM 受体可改善特发性肺纤维化中的纤维化机制。
Am J Respir Crit Care Med. 2018 Jun 1;197(11):1443-1456. doi: 10.1164/rccm.201707-1519OC.
6
Gas6 as a predictor of esophageal varices in patients affected by hepatitis C virus related-chronic liver disease.Gas6作为丙型肝炎病毒相关慢性肝病患者食管静脉曲张的预测指标。
Biomark Med. 2018 Jan;12(1):27-34. doi: 10.2217/bmm-2017-0171. Epub 2017 Dec 15.
7
Soluble TAM receptor tyrosine kinases in rheumatoid arthritis: correlation with disease activity and bone destruction.可溶性 TAM 受体酪氨酸激酶在类风湿关节炎中的表达：与疾病活动度和骨破坏的相关性。
Clin Exp Immunol. 2018 Apr;192(1):95-103. doi: 10.1111/cei.13082. Epub 2017 Dec 11.
8
The non-invasive serum biomarker soluble Axl accurately detects advanced liver fibrosis and cirrhosis.血清非侵入性生物标志物可溶性 Axl 可准确检测晚期肝纤维化和肝硬化。
Cell Death Dis. 2017 Oct 26;8(10):e3135. doi: 10.1038/cddis.2017.554.
9
Gas6 as a putative noninvasive biomarker of hepatic fibrosis.Gas6作为肝纤维化的一种潜在非侵入性生物标志物。
Biomark Med. 2016 Dec;10(12):1241-1249. doi: 10.2217/bmm-2016-0210. Epub 2016 Dec 7.
10
The Gas6/TAM System and Multiple Sclerosis.Gas6/TAM系统与多发性硬化症
Int J Mol Sci. 2016 Oct 28;17(11):1807. doi: 10.3390/ijms17111807.

Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.

作者信息

Sainaghi Pier Paolo, Bellan Mattia, Nerviani Alessandra

机构信息

Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy.

Division of Rheumatology, CAAD (Center for Translational Research on Autoimmune and Allergic Diseases) "AOU Maggiore della Carità", Novara, Italy.

出版信息

Dis Markers. 2021 Jan 13;2021:2854925. doi: 10.1155/2021/2854925. eCollection 2021.

DOI:10.1155/2021/2854925
PMID:33532004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7834835/
Abstract
摘要