He Wanxue, Xiao Kun, Fang Min, Xie Lixin
1College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
2Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Aging Dis. 2021 Feb 1;12(1):277-296. doi: 10.14336/AD.2020.0627. eCollection 2021 Feb.
Sepsis is a form of life-threatening organ dysfunction caused by dysregulated host responses to an infection that can be partly attributed to immune dysfunction. Although sepsis affects patients of all ages, elderly individuals display increased susceptibility and mortality. This is partly due to immunosenescence, a decline in normal immune system function associated with physiological aging that affects almost all cell types in the innate and adaptive immune systems. In elderly patients with sepsis, these alterations in immune cells such as endothelial cells, neutrophils, monocytes, macrophages, natural killer cells, dendritic cells, T lymphocytes, and B lymphocytes, are largely responsible for their poor prognosis and increased mortality. Here, we review recent studies investigating the events affecting both innate and adaptive immune cells in elderly mice and patients with sepsis, including alterations in their number, phenotype, and function, to shed light on possible new therapeutic strategies.
脓毒症是一种由宿主对感染的反应失调引起的危及生命的器官功能障碍，部分可归因于免疫功能障碍。尽管脓毒症影响所有年龄段的患者，但老年人的易感性和死亡率更高。这部分是由于免疫衰老，即与生理衰老相关的正常免疫系统功能下降，几乎影响先天和适应性免疫系统中的所有细胞类型。在老年脓毒症患者中，免疫细胞如内皮细胞、中性粒细胞、单核细胞、巨噬细胞、自然杀伤细胞、树突状细胞、T淋巴细胞和B淋巴细胞的这些改变，在很大程度上导致了他们预后不良和死亡率增加。在此，我们综述了最近关于老年小鼠和脓毒症患者中影响先天和适应性免疫细胞的事件的研究，包括它们数量、表型和功能的改变，以阐明可能的新治疗策略。
