Zhang Chi, Liu Shengzhuo, Peng Liao, Wu Jiapei, Zeng Xiao, Lu Yiping, Shen Hong, Luo Deyi
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Transl Androl Urol. 2021 Jan;10(1):164-173. doi: 10.21037/tau-20-1020.
Inflammatory bowel disease, including ulcerative colitis and Crohn's disease, is characterized by chronic inflammation that could be a risk factor for extraintestinal cancer. The aim of this study is to evaluate whether inflammatory bowel disease is related to the risk of lower urinary tract tumors.
A systematical research was performed on various medical databases including PubMed, the Cochrane Library, Embase and Web of Science from inception to April 2020. Data were independently extracted by two reviewers. The Newcastle-Ottawa Scale and the Oxford Centre for Evidence-Based Medicine criteria were used to assess the quality of included articles. The analysis was completed by STATA version 14.2.
Six hundred and twelve of records were initially identified and 16 studies were included in the final analysis. In general, inflammatory bowel disease patients were not at increased risk of prostate cancer, bladder cancer and male genital cancer. In the subgroup analysis, Crohn's disease patients seemed to have borderline increased risk of prostate cancer [standardized incidence ratio: 1.05; 95% confidence interval (CI): 0.90-1.21; I=15.1%] and bladder cancer (standardized incidence ratio: 1.19; 95% CI: 0.94-1.44; I=0.0%), and ulcerative colitis patients seemed to have borderline increased risk of prostate cancer (standardized incidence ratio: 1.13; 95% CI: 0.93-1.33; I=73.5%).
Inflammatory bowel disease did not significantly increase the risk of prostate cancer, bladder cancer and male genital cancer. Crohn's disease patients seemed to have a higher risk of prostate cancer and bladder cancer, and ulcerative colitis patients seemed to have a higher risk of prostate cancer. ulcerative colitis patients in East Asian countries have significantly increased prostate cancer risk.
炎症性肠病，包括溃疡性结肠炎和克罗恩病，其特征为慢性炎症，这可能是肠外癌症的一个危险因素。本研究的目的是评估炎症性肠病是否与下尿路肿瘤风险相关。
对包括PubMed、考克兰图书馆、Embase和科学网在内的各种医学数据库进行了系统检索，检索时间从建库至2020年4月。数据由两名审阅者独立提取。采用纽卡斯尔-渥太华量表和牛津循证医学中心标准评估纳入文章的质量。分析使用STATA 14.2版完成。
最初识别出612条记录，最终纳入16项研究进行分析。总体而言，炎症性肠病患者患前列腺癌、膀胱癌和男性生殖系统癌症的风险并未增加。在亚组分析中，克罗恩病患者患前列腺癌的风险似乎有临界性增加[标准化发病率比：1.05；95%置信区间（CI）：0.90 - 1.21；I² = 15.1%]和膀胱癌（标准化发病率比：1.19；95% CI：0.94 - 1.44；I² = 0.0%），溃疡性结肠炎患者患前列腺癌的风险似乎有临界性增加（标准化发病率比：1.13；95% CI：0.93 - 1.33；I² = 73.5%）。
炎症性肠病并未显著增加前列腺癌、膀胱癌和男性生殖系统癌症的风险。克罗恩病患者患前列腺癌和膀胱癌的风险似乎较高，溃疡性结肠炎患者患前列腺癌的风险似乎较高。东亚国家的溃疡性结肠炎患者患前列腺癌的风险显著增加。
