Xu Xingyun, Miao Zhigang, Sun Miao, Wan Bo
Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou City, China.
Institute of Neuroscience, Soochow University, Suzhou City, China.
Int J Genomics. 2021 Jan 19;2021:6632719. doi: 10.1155/2021/6632719. eCollection 2021.
The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.
精子细胞的主要生物学功能是将父系遗传和表观遗传信息传递给胚胎以及后续的子代。精子具有独特的表观基因组。越来越多的流行病学研究支持，环境暴露和生活方式所导致的父系应激能够调节精子表观基因组（包括组蛋白修饰、DNA甲基化和非编码RNA表达）、精卵融合、胚胎发育以及子代健康。基于现有文献，我们总结了父系暴露对精子表观基因组的影响、子代的代表性表型以及其中可能涉及的机制。
