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姜黄30%乙醇提取物炎症对急性反流性食管炎大鼠的保护作用

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats.

作者信息

Lee Jin A, Shin Mi-Rae, Kim Min Ju, Lee Ji Hye, Park Hae-Jin, Roh Seong-Soo

机构信息

Department of Herbology, College of Korean Medicine, Daegu Haany University, 136, Shinchendong-ro, Suseong-gu, Daegu 42158, Republic of Korea.

Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.

出版信息

Biomed Res Int. 2021 Jan 16;2021:8854945. doi: 10.1155/2021/8854945. eCollection 2021.

DOI:10.1155/2021/8854945
PMID:33532497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7834798/
Abstract

Gastroesophageal reflux disease (GERD) is induced by the reflux of stomach contents or gastric acid, pepsin into the esophagus for prolonged periods of time due to defection of the lower esophageal sphincter. Reflux esophagitis is a disease found in less than 50% of GERD patients. This study is aimed at evaluating the protective effect of Curcumae longae Rhizoma 30% EtOH extract (CLR) in acute reflux esophagitis (ARE) rats. CLR measured antioxidant activity through experiments. Based on the results, we performed experiments . Before 90 min ARE induction, CLR was administered orally by concentration. ARE was derived by linking the metastatic junction between pylorus and forestomach and corpus in Sprague-Dawley rats. And rats were sacrificed 5 h after surgery. We analyzed the expression of antioxidant and inflammatory-related markers by western blot and observed the production of alanine aminotransferase (ALT), aspartate aminotransferase (AST), reactive oxygen species (ROS), peroxynitrite (ONOO), and thiobarbituric acid reactive substance (TBARS). The administration of CLR reduced esophagus tissue damage in rats with acute reflux esophagitis and decreased the elevated ALT, AST, ROS, ONOO, and TBARS. In addition, CLR effectively increased antioxidant-related factors and reduced inflammatory protein. Overall, these results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE. Overall, CLR treatment informed that markedly ameliorated inactivation of NF-B led to the inhibition of the expressions of proinflammatory proteins. These results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE.

摘要

胃食管反流病（GERD）是由于食管下括约肌功能缺陷，导致胃内容物或胃酸、胃蛋白酶长时间反流至食管所致。反流性食管炎是一种在不到50%的GERD患者中发现的疾病。本研究旨在评估姜黄30%乙醇提取物（CLR）对急性反流性食管炎（ARE）大鼠的保护作用。CLR通过实验测定抗氧化活性。基于这些结果，我们进行了实验。在诱导ARE前90分钟，按浓度口服给予CLR。通过连接Sprague-Dawley大鼠幽门与前胃和胃体之间的转移连接处诱导ARE。术后5小时处死大鼠。我们通过蛋白质印迹法分析抗氧化和炎症相关标志物的表达，并观察丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、活性氧（ROS）、过氧亚硝酸盐（ONOO）和硫代巴比妥酸反应物质（TBARS）的产生。给予CLR可减轻急性反流性食管炎大鼠的食管组织损伤，并降低升高的ALT、AST、ROS、ONOO和TBARS。此外，CLR有效增加抗氧化相关因子并减少炎症蛋白。总体而言，这些结果表明CLR可作为ARE保护和治疗的治疗材料。总体而言，CLR治疗表明，NF-κB的显著改善失活导致促炎蛋白表达的抑制。这些结果表明CLR可作为ARE保护和治疗的治疗材料。

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