Nye Jonathan, D'Souza M Patricia, Hu Dale, Ghosh Dolan
NIAID, MSC 9808, Building 5601, 5601 Fishers Lane, Rockville, Maryland, 20852, USA.
Division of AIDS, NIAID, NIH, Bethesda, Maryland, USA.
Heliyon. 2021 Jan 22;7(1):e06005. doi: 10.1016/j.heliyon.2021.e06005. eCollection 2021 Jan.
The HIV Vaccine Trials Network (HVTN) is the world's largest publicly funded, multi-disciplinary international collaboration facilitating the development of vaccines to prevent HIV/AIDS and has conducted the vast majority of HIV/AIDS clinical trials since its inception in 1999. Although scientific findings from the program have been published in scholarly journals, the impact of a large scientific research network such as the HVTN on the HIV/AIDS vaccine field has not been assessed. This paper describes and elucidates the productivity, influence, and collaboration among HVTN researchers over the last two decades. Our analyses indicate that the HVTN has funded a large number of HIV/AIDS vaccine safety and efficacy clinical trials through a strong global network of clinical sites. In addition, several metrics indicate HVTN researchers also published original research articles that are influential in the HIV vaccine field. Scientific research collaboration is critically important in a complex and multidisciplinary field such as HIV vaccine development as it allows improved sharing of knowledge and expertise as well as the pooling of resources and data. We found that collaboration in the HIV vaccine field increased during this time period and collaboration among HVTN authors increased even more. Combining these productivity, influence, and collaboration metrics with research outcomes can provide a comprehensive assessment of large complex programs such as the HVTN.
艾滋病疫苗试验网络（HVTN）是全球最大的由公共资金资助的多学科国际合作项目，致力于推动预防艾滋病病毒/艾滋病疫苗的研发。自1999年成立以来，该网络开展了绝大多数艾滋病病毒/艾滋病临床试验。尽管该项目的科学研究成果已在学术期刊上发表，但像HVTN这样的大型科研网络对艾滋病病毒/艾滋病疫苗领域的影响尚未得到评估。本文描述并阐明了HVTN研究人员在过去二十年中的生产力、影响力及合作情况。我们的分析表明，HVTN通过强大的全球临床站点网络资助了大量艾滋病病毒/艾滋病疫苗安全性和有效性临床试验。此外，多项指标显示，HVTN研究人员还发表了在艾滋病疫苗领域具有影响力的原创研究文章。在艾滋病疫苗研发这样复杂的多学科领域，科研合作至关重要，因为它能促进知识和专业技能的更好共享，以及资源和数据的汇集。我们发现，在此期间，艾滋病疫苗领域的合作有所增加，HVTN作者之间的合作增加得更多。将这些生产力、影响力和合作指标与研究成果相结合，可以对像HVTN这样的大型复杂项目进行全面评估。
