Acta Chim Slov. 2020 Dec;67(4):1053-1060.
The electrochemical behavior of chlorzoxazone at the carbon paste electrode was investigated in 0.04 mol/L Britton-Robinson buffer pH 6.50 using cyclic and differential pulse voltammetric techniques. Cyclic voltammetric studies indicated that the oxidation of the drug was irreversible and controlled mainly by diffusion. Experimental and instrumental parameters were optimized (50 mV/s scan rate, 50 mV pulse amplitude, and 0.04 mol/L Britton-Robinson (BR) buffer pH 6.50 as a supporting electrolyte) and a sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.17-1.68 µg/mL chlorzoxazone, with detection and quantitation limits of 0.05 and 0.16 µg/mL, respectively. The proposed voltammetric method was successfully applied to the determination of the drug in its pharmaceutical formulation (Myoflex tablets), and in spiked human urine samples.
在 0.04 mol/L Britton-Robinson 缓冲液 pH 6.50 中，使用循环伏安法和差分脉冲伏安法研究了氯唑沙宗在碳糊电极上的电化学行为。循环伏安研究表明，药物的氧化是不可逆的，主要受扩散控制。优化了实验和仪器参数（扫描速率为 50 mV/s，脉冲幅度为 50 mV，支持电解质为 0.04 mol/L Britton-Robinson（BR）缓冲液 pH 6.50），并开发了一种灵敏的差分脉冲阳极伏安法，用于测定药物在 0.17-1.68 µg/mL 氯唑沙宗浓度范围内的含量，检测限和定量限分别为 0.05 和 0.16 µg/mL。该伏安法成功应用于其药物制剂（Myoflex 片剂）和加标人尿样中药物的测定。
