导电聚甲硫氨酸/金纳米颗粒修饰传感器在帕罗西汀电化学检测中的应用。

Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine.

作者信息

Al-Mhyawi Saedah R, Ahmed Riham K, El Nashar Rasha M

机构信息

Department of Chemistry, College of Science, University of Jeddah, Jeddah 22233, Saudi Arabia.

Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.

出版信息

Polymers (Basel). 2021 Nov 17;13(22):3981. doi: 10.3390/polym13223981.

This work demonstrates a facile electropolymerization of a dl-methionine (dl-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon electrode (GCE). The resulting sensor was successfully applied for the sensitive detection of paroxetine·HCl (PRX), a selective serotonin (5-HT) reuptake inhibitor (SSRIs), in its pharmaceutical formulations. The sensor was characterized morphologically using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) and electrochemical techniques such as differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The proposed sensor, poly (dl-met)/AuNPs-GCE, exhibited a linear response range from 5 × 10 to 5 × 10 M and from 5 × 10 to 1 × 10 M using DPV with lowest limit of detection (LOD = 1 × 10 M) based on (S/N = 3). The poly (dl-met)/AuNPs-GCE sensor was successfully applied for PRX determination in three different pharmaceutical formulations with percent recoveries between 96.29% and 103.40% ± SD (±0.02 and ±0.58, respectively).

这项工作展示了在金纳米颗粒（AuNPs）修饰的玻碳电极（GCE）上简便地电聚合dl-蛋氨酸（dl-met）导电聚合物膜。所得传感器成功应用于其药物制剂中选择性5-羟色胺（5-HT）再摄取抑制剂（SSRIs）盐酸帕罗西汀（PRX）的灵敏检测。使用扫描电子显微镜（SEM）结合能量色散X射线光谱（EDX）和原子力显微镜（AFM）对传感器进行形态表征，并采用差分脉冲伏安法（DPV）、电化学阻抗谱（EIS）和循环伏安法（CV）等电化学技术。所提出的聚（dl-met）/AuNPs-GCE传感器，基于（S/N = 3），使用DPV时线性响应范围为5×10至5×10 M以及5×10至1×10 M，最低检测限（LOD = 1×10 M）。聚（dl-met）/AuNPs-GCE传感器成功应用于三种不同药物制剂中PRX的测定，回收率在96.29%至103.40%±SD（分别为±0.02和±0.58）之间。