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上皮性卵巢癌列线图的建立与验证:基于 SEER 的真实世界研究。

Development and validation of nomograms for epithelial ovarian cancer: a SEER population-based, real-world study.

机构信息

Department of Obstetrics & Gynecology, Maternal & Child Health Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.

School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China.

出版信息

Future Oncol. 2021 Mar;17(8):893-906. doi: 10.2217/fon-2020-0531. Epub 2021 Feb 3.

Abstract

To develop and internally validate nomograms to predict the overall survival (OS) and the cancer-specific survival (CSS) of patients with epithelial ovarian cancer (EOC). A total of 9001 EOC patients diagnosed between 2010 and 2013 were randomly divided into the training (n = 6301) and validation (n = 2700) cohorts. Nomogram and bootstrap validation were used to assess the predictive values of the models, including discrimination, calibration and clinical benefit. In the validation cohort, the concordance statistic values were 0.733 for OS and 0.747 for CSS. Calibration plots and decision curve analyses demonstrated moderate accuracy and clinical applicability. Nomograms were user-friendly tools for guiding clinical treatment and estimating prognosis.

摘要

目的

开发并内部验证列线图,以预测上皮性卵巢癌(EOC)患者的总生存(OS)和癌症特异性生存(CSS)。

方法

共纳入 9001 例 2010 年至 2013 年间诊断为 EOC 的患者,将其随机分为训练队列(n=6301)和验证队列(n=2700)。采用列线图和 bootstrap 验证评估模型的预测价值,包括区分度、校准度和临床获益。

结果

在验证队列中,OS 的一致性统计量值为 0.733,CSS 的一致性统计量值为 0.747。校准图和决策曲线分析显示出中等准确性和临床适用性。列线图是指导临床治疗和估计预后的有用工具。

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