Department of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India.
Division of Thoracic Surgery, Medstar Washington Hospital Center, Georgetown University School of Medicine, Washington, DC, USA.
J Cancer Res Ther. 2022 Jul-Sep;18(4):873-879. doi: 10.4103/jcrt.JCRT_12_19.
Gastric Carcinoma (GC) is one of the most common malignancies, which accounts for 6.8% of total cancer population worldwide. In India, the northeastern region has the highest gastric cancer incidence, and the Kashmir Valley has a very high incidence of gastric cancer as compared to other parts of Northern India. It exceeds 40% of total cancers with an incidence rate of 3-6-fold higher than other metro cities of India. Gastric cancer is a heterogeneous disease where most of the cases are sporadic, and <15% are due to obvious familial clustering. The heterogeneous nature of the disease can be associated with differences in genetic makeup of an individual. A better understanding of genetic predisposition toward GC will be helpful in promoting personalized medicine. The aim of this review is to analyze the development and progression of GC and to explore the genetic perspectives of the disease with special emphasis on Jammu and Kashmir, India.
胃癌（GC）是最常见的恶性肿瘤之一，占全球癌症总人群的 6.8%。在印度，东北地区的胃癌发病率最高，而克什米尔山谷的胃癌发病率相对于印度其他北部地区非常高。它超过了总癌症的 40%，发病率比印度其他大都市高出 3-6 倍。胃癌是一种异质性疾病，其中大多数病例是散发性的，<15%是由于明显的家族聚集。疾病的异质性可能与个体遗传构成的差异有关。更好地了解 GC 的遗传易感性将有助于促进个性化医学。本综述的目的是分析 GC 的发展和进展，并探讨该疾病的遗传观点，特别强调印度查谟和克什米尔。
