Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Toxic Rep Ser. 2019 Aug(96). doi: 10.22427/NTP-TOX-96.
Widespread exposure to several per/polyfluorinated alkyl substances (PFAS) is associated with a variety of toxicities that include liver and endocrine toxicity. The National Toxicology Program (NTP) conducted 28-day toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats (n = 10/dose; five doses per chemical) to compare the toxicities of seven PFAS (three sulfonic acids or salt: perfluorobutane sulfonic acid [PFBS], perfluorohexane sulfonate potassium salt [PFHxSK], and perfluorooctane sulfonic acid [PFOS], and four carboxylates) via gavage in deionized water with 2% Tween 80. This report describes the studies for the two sulfonic acids (PFBS and PFOS) and salt (PFHxSK); a companion report (NTP Toxicity Study Report 97) describes the studies for the PFAS carboxylates. Doses were 0 to 1,000 mg/kg/day for PFBS, 0 to 10 mg/kg/day for PFHxSK males, 0 to 50 mg/kg/day for PFHxSK females, and 0 to 5 mg/kg/day for PFOS. (Abstract Abridged).
广泛接触多种全氟/多氟烷基物质（PFAS）与包括肝脏和内分泌毒性在内的多种毒性相关。美国国家毒理学计划（NTP）在雄性和雌性斯普拉格-道利（Hsd:Sprague Dawley SD）大鼠中进行了为期28天的毒性研究（每组10只；每种化学品5个剂量组），以比较7种PFAS（3种磺酸或盐：全氟丁烷磺酸[PFBS]、全氟己烷磺酸钾盐[PFHxSK]和全氟辛烷磺酸[PFOS]，以及4种羧酸盐）经口灌胃给予含2%吐温80的去离子水后的毒性。本报告描述了两种磺酸（PFBS和PFOS）及盐（PFHxSK）的研究；另一篇配套报告（NTP毒性研究报告97）描述了PFAS羧酸盐的研究。PFBS的剂量为0至1000毫克/千克/天，PFHxSK雄性大鼠的剂量为0至10毫克/千克/天，PFHxSK雌性大鼠的剂量为0至50毫克/千克/天，PFOS的剂量为0至5毫克/千克/天。（摘要节略）
