Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Toxic Rep Ser. 2019 Aug(97). doi: 10.22427/NTP-TOX-97.
Widespread exposure to several per/polyfluorinated alkyl substances (PFAS) is associated with a wide array of toxicities. The National Toxicology Program (NTP) conducted 28-day toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats (n = 10/dose; five doses) to compare the toxicities of seven PFAS chemicals (three sulfonic acids or salt: perfluorobutane sulfonic acid, perfluorohexane sulfonate potassium salt, and perfluorooctane sulfonic acid; and four carboxylates: perfluorohexanoic acid [PFHxA], perfluorooctanoic acid [PFOA], perfluorononanoic acid [PFNA], and perfluorodecanoic acid [PFDA]) via gavage in deionized water with 2% Tween 80. This report describes the studies of the four carboxylates (PFHxA, PFOA, PFNA, and PFDA); a companion report (NTP Toxicity Study Report 96) describes the studies of the three PFAS sulfonates. Doses were 0 to 1,000 mg/kg/day for PFHxA, 0 to 10 mg/kg/day for PFOA males, 0 to 100 mg/kg/day for PFOA females, 0 to 10 mg/kg/day for PFNA males, 0 to 25 mg/kg/day for PFNA females, and 0 to 2.5 mg/kg/day for PFDA. (Abstract Abridged).
广泛接触多种全氟/多氟烷基物质（PFAS）与一系列毒性相关。美国国家毒理学计划（NTP）在雄性和雌性斯普拉格·道利（Hsd:Sprague Dawley SD）大鼠（每组10只；共五组剂量）中进行了为期28天的毒性研究，以比较七种PFAS化学品（三种磺酸或盐：全氟丁烷磺酸、全氟己烷磺酸钾盐和全氟辛烷磺酸；以及四种羧酸盐：全氟己酸[PFHxA]、全氟辛酸[PFOA]、全氟壬酸[PFNA]和全氟癸酸[PFDA]）经口灌胃给予含2%吐温80的去离子水后的毒性。本报告描述了四种羧酸盐（PFHxA、PFOA、PFNA和PFDA）的研究；一份配套报告（NTP毒性研究报告96）描述了三种PFAS磺酸盐的研究。PFHxA的剂量为0至1000毫克/千克/天，PFOA雄性的剂量为0至10毫克/千克/天，PFOA雌性的剂量为0至100毫克/千克/天，PFNA雄性的剂量为0至10毫克/千克/天，PFNA雌性的剂量为0至25毫克/千克/天，PFDA的剂量为0至2.5毫克/千克/天。（摘要节略）
