慢性地昔帕明治疗后大鼠GABA能受体活性改变的功能证据。
Functional evidence for altered activity of GABAergic receptors following chronic desipramine treatment in rats.
作者信息
Borsini F, Giuliani S, Meli A
出版信息
J Pharm Pharmacol. 1986 Dec;38(12):934-5. doi: 10.1111/j.2042-7158.1986.tb03389.x.
The antinociceptive effect of subcutaneous 4,5,6,7-tetrahydroisoxazol[5,4-c]pyridin-3-ol (THIP) or (+/-)-baclofen, measured as reaction time of rats placed on a plate heated to 55 degrees C, was assessed after a single or the last repeated (18 consecutive days) dose (5 mg kg-1 once daily) of subcutaneous desipramine. Baclofen (10 mg kg-1)-induced antinociception was reduced by acute and unaffected by chronic desipramine treatment. On the contrary, THIP (20 mg kg-1)-induced antinociception was unaffected by acute and reduced by chronic desipramine.
以置于加热至55摄氏度平板上的大鼠反应时间来衡量，在单次或最后一次重复（连续18天）皮下给予地昔帕明（每日一次，5 mg/kg）后，评估皮下注射4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇（THIP）或（±）-巴氯芬的抗伤害感受作用。急性给予地昔帕明可降低巴氯芬（10 mg/kg）诱导的抗伤害感受，而慢性给予地昔帕明则无影响。相反，急性给予地昔帕明对THIP（20 mg/kg）诱导的抗伤害感受无影响，而慢性给予地昔帕明则使其降低。
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