Pulvirenti L, Kastin A J
VA Medical Center, New Orleans, LA 70146.
Pharmacol Biochem Behav. 1988 Sep;31(1):129-34. doi: 10.1016/0091-3057(88)90323-1.
The possible relationship between the actions of ethanol and opiates led us to examine the effect of opiate antagonists on ethanol intake in rats with a free choice of water. Naloxone (NAL) significantly reduced intake of ethanol. This effect was much greater in "high-preferring" (ethanol/total fluid intake greater than 60%) than in "low-preferring" (ethanol/total fluid intake less than 30%) rats. Furthermore, a correlation was found between the degree of spontaneous preference (ethanol/total fluid intake ratio) and the reduction of ethanol drinking by NAL. Sensitivity to NAL increased with increased preference for ethanol. Neither Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) nor MIF-1 (Pro-Leu-Gly-NH2) caused a significant modification of ethanol intake. This study shows that NAL can reduce volitional ethanol intake in rats and provides further evidence that Tyr-MIF-1 does not always act like NAL.
乙醇与阿片类药物作用之间可能存在的关系，促使我们研究阿片类拮抗剂对可自由选择饮水的大鼠乙醇摄入量的影响。纳洛酮（NAL）显著降低了乙醇摄入量。这种作用在“高偏好”（乙醇/总液体摄入量大于60%）大鼠中比在“低偏好”（乙醇/总液体摄入量小于30%）大鼠中更为明显。此外，还发现自发偏好程度（乙醇/总液体摄入量比率）与NAL对乙醇饮用量的降低之间存在相关性。对NAL的敏感性随对乙醇偏好的增加而增加。酪酪肽（Tyr-MIF-1，Tyr-Pro-Leu-Gly-NH2）和促黑素细胞激素（MIF-1，Pro-Leu-Gly-NH2）均未引起乙醇摄入量的显著改变。本研究表明，NAL可降低大鼠的自愿性乙醇摄入量，并进一步证明酪酪肽的作用并不总是与纳洛酮相同。
