单侧翼状胬肉的泪液和血清维生素 D 浓度。

Tear Fluid and Serum Vitamin D Concentrations in Unilateral Pterygium.

机构信息

Department of Ophthalmology, School of Medicine, Kırıkkale University, Kırıkkale, Turkey.

出版信息

Optom Vis Sci. 2021 Feb 1;98(2):170-174. doi: 10.1097/OPX.0000000000001640.

DOI:10.1097/OPX.0000000000001640

PMID:33534378

Abstract

SIGNIFICANCE

Vitamin D has antiangiogenic, anti-inflammatory, and antifibrotic properties, which may play an inhibitory role on pterygium formation. Vitamin D concentration was measured in few studies, and contradictory results have been reported. There is no study investigating tear fluid concentration of vitamin D in pterygium patients.

PURPOSE

This study evaluated tear fluid and serum vitamin D concentrations of pterygium patients in comparison with healthy controls.

METHODS

Thirty-five (21 male, 14 female) patients with unilateral pterygium and 25 (18 male, 7 female) healthy controls were included in this case-control study. After full ophthalmic examination, blood samples were taken, and basal tear fluid was collected using glass microcapillary tubes. Tear fluid and serum vitamin D concentrations were analyzed using enzyme-linked immunosorbent assay and analyzed statistically.

RESULTS

The mean ± standard deviation age of patients was 51.7 ± 16.7 years in the study group and 50.6 ± 18.7 years in the control group, respectively (P = .82). The mean tear fluid vitamin D concentration was statistically significantly higher than the mean serum concentration in the study groups (P < .0001). The mean tear fluid (P = .76) and serum vitamin D concentrations (P = .53) did not reveal statistically significant difference between patients and controls. There was no statistically significant difference for tear fluid vitamin D concentration between pterygium eyes and fellow eyes (P = .93). The difference in concentrations was compared within the pterygium subgroups, and it was found that the mean serum vitamin D concentration trended toward lower values as the stage of pterygium increased, and the mean tear fluid vitamin D concentration trended toward higher values as the stage of pterygium increased, although these differences were not statistically significant (all, P > .05).

CONCLUSIONS

Tear fluid and serum vitamin D concentrations do not seem to have a role in pterygium pathogenesis.

摘要

意义

维生素 D 具有抗血管生成、抗炎和抗纤维化特性，这可能对翼状胬肉的形成起抑制作用。已有少数研究测量了维生素 D 浓度，但报告的结果相互矛盾。目前尚无研究调查翼状胬肉患者的泪液中维生素 D 浓度。

目的

本研究评估了翼状胬肉患者与健康对照者的泪液和血清维生素 D 浓度。

方法

这项病例对照研究纳入了 35 名（21 名男性，14 名女性）单侧翼状胬肉患者和 25 名（18 名男性，7 名女性）健康对照者。全面眼科检查后，采集血样，并使用玻璃微量吸管收集基础泪液。使用酶联免疫吸附试验分析泪液和血清维生素 D 浓度，并进行统计学分析。

结果

研究组患者的平均（±标准差）年龄为 51.7 ± 16.7 岁，对照组为 50.6 ± 18.7 岁（P =.82）。研究组的平均泪液维生素 D 浓度明显高于平均血清浓度（P <.0001）。患者与对照组的平均泪液（P =.76）和血清维生素 D 浓度（P =.53）无统计学显著差异。翼状胬肉眼与对侧眼的泪液维生素 D 浓度无统计学显著差异（P =.93）。在翼状胬肉亚组内比较浓度差异，发现血清维生素 D 浓度随着翼状胬肉分期的增加而呈下降趋势，而泪液维生素 D 浓度随着翼状胬肉分期的增加而呈上升趋势，但这些差异无统计学意义（均 P >.05）。