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Hunting for a Diagnosis.

作者信息

Houchens Nathan, Hartley Sarah, Commins Scott P, Claar Dru, Saint Sanjay

机构信息

From the Veterans Affairs (VA) Ann Arbor Healthcare System Medicine Service (N.H., S.H, D.C., S.S.), the Department of Internal Medicine, University of Michigan Medical School (N.H., S.H, D.C., S.S.), and the Department of VA Health Services Research and Development Center of Excellence (S.S.) - all in Ann Arbor; and the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill (S.P.C.).

出版信息

N Engl J Med. 2021 Feb 4;384(5):462-467. doi: 10.1056/NEJMcps2017588.

DOI:10.1056/NEJMcps2017588
PMID:33534979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9306225/
Abstract
摘要

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Hunting for a Diagnosis.寻找诊断结果
N Engl J Med. 2021 Feb 4;384(5):462-467. doi: 10.1056/NEJMcps2017588.
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Mammalian meat allergy.哺乳动物肉过敏。
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Delayed red meat allergy: clinical ramifications of galactose-α-1,3-galactose sensitization.迟发性红肉过敏：α-1,3-半乳糖致敏的临床后果
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Delayed urticaria or anaphylaxis after consumption of red meat with evidence of alpha-gal sensitisation.食用红肉后出现延迟性荨麻疹或过敏反应，伴有α-半乳糖致敏证据。
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Delayed anaphylaxis to red meat masquerading as idiopathic anaphylaxis.伪装成特发性过敏反应的红肉迟发性过敏反应。
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What Is Alpha-Gal Syndrome?什么是α-半乳糖综合征？
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Delayed mammalian meat-induced anaphylaxis confirmed by skin test to cetuximab.通过西妥昔单抗皮肤试验确诊的迟发性哺乳动物肉类诱发过敏反应。
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Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab.哺乳动物肉类诱发的过敏反应：通过对西妥昔单抗进行皮肤试验证实的抗半乳糖-α-1,3-半乳糖 IgE 的临床相关性。
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引用本文的文献

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Alpha-Gal Syndrome: Often Hidden, Under-Recognized, and in Need of Attention-A Rapid Review.α-半乳糖综合征：常被隐匿、认识不足且亟需关注——快速综述
Int J Gen Med. 2025 Jun 27;18:3477-3488. doi: 10.2147/IJGM.S519844. eCollection 2025.
2
The α-Gal epitope - the cause of a global allergic disease.α-半乳糖表位——一种全球过敏性疾病的病因。
Front Immunol. 2024 Jan 22;15:1335911. doi: 10.3389/fimmu.2024.1335911. eCollection 2024.
3
Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome.α-半乳糖综合征中 Th2 偏向的 T 细胞与 B 细胞对 α-半乳糖和蜱抗原的反应相关。

本文引用的文献

1
Diagnostic testing for galactose-alpha-1,3-galactose, United States, 2010 to 2018.2010 年至 2018 年美国半乳糖-α-1,3-半乳糖的诊断检测。
Ann Allergy Asthma Immunol. 2021 Apr;126(4):411-416.e1. doi: 10.1016/j.anai.2020.12.019. Epub 2021 Jan 7.
2
Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients.α-半乳糖苷综合征的诊断与管理：2500 例患者的经验教训。
Expert Rev Clin Immunol. 2020 Jul;16(7):667-677. doi: 10.1080/1744666X.2020.1782745. Epub 2020 Jul 8.
3
Bracing for the Worst - Range Expansion of the Lone Star Tick in the Northeastern United States.
J Clin Invest. 2023 Mar 15;133(6):e158357. doi: 10.1172/JCI158357.
4
Northward Expansion of Amblyomma americanum (Acari: Ixodidae) into Southwestern Michigan.美洲钝眼蜱（蜱螨目：硬蜱科）向密歇根州西南部的北扩。
J Med Entomol. 2022 Sep 14;59(5):1646-1659. doi: 10.1093/jme/tjac082.
5
The expanding spectrum of disease caused by the Lone Star Tick, Amblyomma americanum.由美洲钝眼蜱（孤星蜱）引起的疾病谱正在扩大。
Infez Med. 2021 Sep 10;29(3):378-385. doi: 10.53854/liim-2903-8. eCollection 2021.
为最坏情况做准备——美国东北部孤星蜱的分布范围扩张
N Engl J Med. 2019 Dec 5;381(23):2189-2192. doi: 10.1056/NEJMp1911661.
4
Only α-Gal bound to lipids, but not to proteins, is transported across enterocytes as an IgE-reactive molecule that can induce effector cell activation.只有与脂质结合的 α-半乳糖，而不是与蛋白质结合的 α-半乳糖，才能作为一种可诱导效应细胞激活的 IgE 反应性分子被转运穿过肠细胞。
Allergy. 2019 Oct;74(10):1956-1968. doi: 10.1111/all.13873. Epub 2019 Jul 16.
5
Investigation into the α-Gal Syndrome: Characteristics of 261 Children and Adults Reporting Red Meat Allergy.α-半乳糖综合征研究：261 名报告红肉过敏的儿童和成人的特征。
J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2348-2358.e4. doi: 10.1016/j.jaip.2019.03.031. Epub 2019 Mar 30.
6
Tick-induced allergies: mammalian meat allergy and tick anaphylaxis.蜱诱发的过敏反应：哺乳动物肉过敏和蜱过敏反应。
Med J Aust. 2018 Apr 16;208(7):316-321. doi: 10.5694/mja17.00591.
7
The alpha-gal story: lessons learned from connecting the dots.α-半乳糖的故事：从梳理线索中汲取的教训。
J Allergy Clin Immunol. 2015 Mar;135(3):589-96; quiz 597. doi: 10.1016/j.jaci.2014.12.1947.
8
The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.蜱虫叮咬与产生针对哺乳动物寡糖半乳糖-α-1,3-半乳糖的 IgE 抗体的相关性。
J Allergy Clin Immunol. 2011 May;127(5):1286-93.e6. doi: 10.1016/j.jaci.2011.02.019. Epub 2011 Mar 31.
9
Food allergy to meat and milk in adults.成人对肉类和牛奶的食物过敏。
Allergy. 2010 Aug;65(8):1065-7. doi: 10.1111/j.1398-9995.2009.02293.x. Epub 2009 Dec 11.
10
Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose.对于具有针对半乳糖-α-1,3-半乳糖的IgE抗体的患者，食用红肉后出现迟发性过敏反应、血管性水肿或荨麻疹。
J Allergy Clin Immunol. 2009 Feb;123(2):426-33. doi: 10.1016/j.jaci.2008.10.052. Epub 2008 Dec 13.