Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090, Vienna, Austria.
Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090, Vienna, Austria; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria.
Curr Opin Chem Biol. 2021 Apr;61:123-134. doi: 10.1016/j.cbpa.2020.12.005. Epub 2021 Jan 31.
Undoubtedly, metallomic approaches based on mass spectrometry have evolved into essential tools supporting the drug development of novel metal-based anticancer drugs. This article will comment on the state-of-the-art instrumentation and highlight some of the recent analytical advances beyond routine, especially focusing on the latest developments in inductively coupled plasma-mass spectrometry (ICP-MS). Mass spectrometry-based bioimaging and single-cell methods will be presented, paving the way to exciting investigations of metal-based anticancer drugs in heterogeneous and structurally, as well as functionally complex solid tumor tissues.
毫无疑问，基于质谱的金属组学方法已经发展成为支持新型基于金属的抗癌药物开发的重要工具。本文将评论最先进的仪器，并强调一些常规之外的最新分析进展，特别是聚焦于电感耦合等离子体质谱（ICP-MS）的最新进展。将介绍基于质谱的生物成像和单细胞方法，为在异质的、结构和功能复杂的实体瘤组织中研究基于金属的抗癌药物铺平道路。
