Thomas F, Cosset J M, Cherel P, Renaudy N, Carde P, Piekarski J D
Département des radiations, Institut Gustave Roussy, Villejuif, France.
Radiother Oncol. 1988 Feb;11(2):119-22. doi: 10.1016/0167-8140(88)90247-2.
Sequential thoracic CT-scanning was performed for 14 patients presenting with residual mediastinal masses on chest X-ray after treatment of stage I and II Hodgkin's disease (HD). Eleven patients initially presented with bulky mediastinal involvement. No mediastinal biopsy was performed. No local recurrence was detected at a 48 month median follow-up. Early evaluation by CT-scanning showed cystic degeneration in three cases. Sequential CT-scans on longer follow-up demonstrated continuous regression of residual masses in six cases and no or limited volume reduction in six other cases. In two patients, part of the residual mass remained stable and the other part showed reduction in size. In addition, late calcifications developed in four cases. The results of sequential CT-scanning suggest that residual mediastinal masses do not generally represent active disease. Hence additional, potentially toxic, therapy can be avoided.
对14例I期和II期霍奇金病（HD）治疗后胸部X线显示纵隔残留肿块的患者进行了序贯胸部CT扫描。11例患者最初表现为纵隔大块受累。未进行纵隔活检。在中位随访48个月时未检测到局部复发。早期CT扫描评估显示3例有囊性变。更长时间随访的序贯CT扫描显示，6例残留肿块持续缩小，另外6例肿块体积无缩小或仅有有限缩小。2例患者，残留肿块一部分保持稳定，另一部分体积缩小。此外，4例出现晚期钙化。序贯CT扫描结果提示纵隔残留肿块一般不代表活动性疾病。因此可避免额外的、可能有毒性的治疗。
