• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

PPAR-γ 基因多态性与缺血性脑卒中风险的关系：一项荟萃分析。

Relationship between PPAR-γ gene polymorphisms and ischemic stroke risk: A meta-analysis.

机构信息

Center of Cardiopulmonary Rehabilitation, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Department of Neurology, Taihe Hospital, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China.

出版信息

Brain Behav. 2021 Dec;11(12):e2434. doi: 10.1002/brb3.2434. Epub 2021 Nov 10.

DOI:10.1002/brb3.2434
PMID:34758198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8671800/
Abstract

BACKGROUND

Published researches have suggested some associations between PPAR-γ and ischemic stroke (IS) development. This meta-analysis was conducted to evaluate the association between PPAR-γ gene polymorphisms and IS risk.

MATERIALS AND METHODS

A systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR-γ rs1801282 C/G and rs3856806 C/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted.

RESULT

Sixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated that rs1801282 C/G polymorphism may be associated with an increased risk for IS (GG vs. CC: OR = 2.17 95%CI = 1.09-4.35, p = .03, I = 0%; GG vs. CC+CG: OR = 2.15, 95%CI = 1.07-4.32, p = .03, I = 0%). The similar results were also found in the subgroup analysis. In addition, no significant association was observed between rs3856806 C/T polymorphism and IS risk.

CONCLUSION

In conclusion, our study showed that PPAR-γ rs1801282 C/G polymorphism probably plays an important role in IS occurrence. The result should be verified with more studies in the future.

摘要

背景

已发表的研究表明，过氧化物酶体增殖物激活受体-γ（PPAR-γ）与缺血性脑卒中（IS）的发展之间存在某些关联。本荟萃分析旨在评估 PPAR-γ 基因多态性与 IS 风险之间的关系。

材料与方法

系统检索了 PubMed、Embase、Web of Science、中国知网和万方数据库，计算比值比（OR）及其 95%置信区间（CI）的合并值，以评估 PPAR-γ rs1801282 C/G 和 rs3856806 C/T 多态性与 IS 风险的关系。此外，还进行了异质性检验、累积分析、敏感性分析和发表偏倚分析。

结果

共纳入 16 项研究，包含 3786 例病例和 5343 例对照。总体结果表明，rs1801282 C/G 多态性可能与 IS 风险增加相关（GG 与 CC：OR=2.17，95%CI=1.09-4.35，p=0.03，I=0%；GG 与 CC+CG：OR=2.15，95%CI=1.07-4.32，p=0.03，I=0%）。亚组分析也得到了类似的结果。此外，rs3856806 C/T 多态性与 IS 风险之间未见显著关联。

结论

综上所述，本研究表明，PPAR-γ rs1801282 C/G 多态性可能在 IS 发生中起重要作用。该结果有待未来更多研究加以验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/506c26657a34/BRB3-11-e2434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/f15a70c8da15/BRB3-11-e2434-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/ccd1a5b94279/BRB3-11-e2434-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/3ecca1601044/BRB3-11-e2434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/afbf1a30774f/BRB3-11-e2434-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/506c26657a34/BRB3-11-e2434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/f15a70c8da15/BRB3-11-e2434-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/ccd1a5b94279/BRB3-11-e2434-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/3ecca1601044/BRB3-11-e2434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/afbf1a30774f/BRB3-11-e2434-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c3/8671800/506c26657a34/BRB3-11-e2434-g002.jpg

相似文献

1
Relationship between PPAR-γ gene polymorphisms and ischemic stroke risk: A meta-analysis.PPAR-γ 基因多态性与缺血性脑卒中风险的关系：一项荟萃分析。
Brain Behav. 2021 Dec;11(12):e2434. doi: 10.1002/brb3.2434. Epub 2021 Nov 10.
2
Lack of genetic associations between PPAR-γ gene rs1801282 polymorphism and Alzheimer's disease in general population: a meta-analysis.一般人群中PPAR-γ基因rs1801282多态性与阿尔茨海默病之间缺乏遗传关联：一项荟萃分析。
Gene. 2015 Jun 1;563(2):120-4. doi: 10.1016/j.gene.2015.03.014. Epub 2015 Mar 11.
3
Association between gene polymorphisms and diabetic retinopathy risk: a meta-analysis.基因多态性与糖尿病视网膜病变风险的关联：荟萃分析。
Aging (Albany NY). 2021 Feb 1;13(4):5136-5149. doi: 10.18632/aging.202433.
4
G Allele of the rs1801282 Polymorphism in PPARγ Gene Confers an Increased Risk of Obesity and Hypercholesterolemia, While T Allele of the rs3856806 Polymorphism Displays a Protective Role Against Dyslipidemia: A Systematic Review and Meta-Analysis.rs1801282 多态性的 G 等位基因使 PPARγ 基因易患肥胖和高胆固醇血症，而 rs3856806 多态性的 T 等位基因对血脂异常具有保护作用：系统评价和荟萃分析。
Front Endocrinol (Lausanne). 2022 Jun 29;13:919087. doi: 10.3389/fendo.2022.919087. eCollection 2022.
5
Association between Peroxisome Proliferator-activated Receptor Gamma Gene Polymorphisms and Atherosclerotic Diseases: A Meta-analysis of Case-control Studies.过氧化物酶体增殖物激活受体γ基因多态性与动脉粥样硬化性疾病的关联：病例对照研究的荟萃分析
J Atheroscler Thromb. 2015;22(9):912-25. doi: 10.5551/jat.26138. Epub 2015 Apr 1.
6
The meta-analysis of the association of PPARG P12A, C161T polymorphism and coronary heart disease.PPARG P12A、C161T 多态性与冠心病的关联的荟萃分析。
Wien Klin Wochenschr. 2012 Oct;124(19-20):671-7. doi: 10.1007/s00508-012-0223-0. Epub 2012 Sep 18.
7
Association between genetic polymorphisms and ischemic stroke risk in a northern Chinese Han population: a case-control study.中国北方汉族人群基因多态性与缺血性中风风险的关联：一项病例对照研究。
Neural Regen Res. 2019 Nov;14(11):1986-1993. doi: 10.4103/1673-5374.259621.
8
Association between peroxisome proliferator-activated receptor-alpha, delta, and gamma polymorphisms and risk of coronary heart disease: A case-control study and meta-analysis.过氧化物酶体增殖物激活受体α、δ和γ基因多态性与冠心病风险的关联：一项病例对照研究及荟萃分析
Medicine (Baltimore). 2016 Aug;95(32):e4299. doi: 10.1097/MD.0000000000004299.
9
Associations of Leptin Receptor and Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis.瘦素受体和过氧化物酶体增殖物激活受体 γ 多态性与多囊卵巢综合征的关联：一项荟萃分析。
Ann Nutr Metab. 2019;75(1):1-8. doi: 10.1159/000500996. Epub 2019 Aug 14.
10
C-reactive Protein -717A>G and -286C>T>A Gene Polymorphism and Ischemic Stroke.C反应蛋白-717A>G和-286C>T>A基因多态性与缺血性脑卒中
Chin Med J (Engl). 2015 Jun 20;128(12):1666-70. doi: 10.4103/0366-6999.158371.

引用本文的文献

1
Interleukins 10 and 1β gene polymorphisms in ischemic stroke risk in the Egyptian population.埃及人群中白细胞介素10和1β基因多态性与缺血性中风风险的关系
Sci Rep. 2025 May 14;15(1):16792. doi: 10.1038/s41598-025-98531-w.
2
Identification and prediction of molecular factors associated with ischemic stroke: an integrative analysis of DEGs, TFs, and PPI networks.与缺血性中风相关的分子因素的识别与预测：差异表达基因、转录因子和蛋白质-蛋白质相互作用网络的综合分析
In Vitro Model. 2023 Dec 7;2(6):307-315. doi: 10.1007/s44164-023-00063-y. eCollection 2023 Dec.
3
Common Genetic Factors and Pathways in Alzheimer's Disease and Ischemic Stroke: Evidences from GWAS.

本文引用的文献

1
Associations between peroxisome proliferator-activated receptor γ (PPAR-γ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults.过氧化物酶体增殖物激活受体 γ（PPAR-γ）多态性与血清脂质的关联：两项社区成年人群的横断面研究。
Gene. 2020 Dec 15;762:145019. doi: 10.1016/j.gene.2020.145019. Epub 2020 Aug 2.
2
Atorvastatin protects against postoperative neurocognitive disorder via a peroxisome proliferator-activated receptor-gamma signaling pathway in mice.阿托伐他汀通过过氧化物酶体增殖物激活受体-γ信号通路保护小鼠术后神经认知障碍。
J Int Med Res. 2020 May;48(5):300060520924251. doi: 10.1177/0300060520924251.
3
阿尔茨海默病和缺血性中风的常见遗传因素和途径：来自 GWAS 的证据。
Genes (Basel). 2023 Jan 30;14(2):353. doi: 10.3390/genes14020353.
Propane-2-sulfonic acid octadec-9-enyl-amide, a novel peroxisome proliferator-activated receptors α and γ dual agonist, enhances hippocampal neurogenesis and neuroplasticity in rats with cerebral ischaemia.
丙烷-2-磺酸十八碳-9-烯基酰胺，一种新型过氧化物酶体增殖物激活受体α和γ双重激动剂，可增强脑缺血大鼠的海马神经发生和神经可塑性。
Neuroreport. 2019 Dec 18;30(18):1299-1306. doi: 10.1097/WNR.0000000000001360.
4
Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack.过氧化物酶体增殖物激活受体γ激动剂用于预防中风或短暂性脑缺血发作患者的复发性中风和其他血管事件。
Cochrane Database Syst Rev. 2019 Oct 9;10(10):CD010693. doi: 10.1002/14651858.CD010693.pub5.
5
Association between genetic polymorphisms and ischemic stroke risk in a northern Chinese Han population: a case-control study.中国北方汉族人群基因多态性与缺血性中风风险的关联：一项病例对照研究。
Neural Regen Res. 2019 Nov;14(11):1986-1993. doi: 10.4103/1673-5374.259621.
6
Fibroblast growth factor 21 enhances angiogenesis and wound healing of human brain microvascular endothelial cells by activating PPARγ.成纤维细胞生长因子 21 通过激活 PPARγ 增强人脑微血管内皮细胞的血管生成和伤口愈合。
J Pharmacol Sci. 2019 Jun;140(2):120-127. doi: 10.1016/j.jphs.2019.03.010. Epub 2019 Jun 15.
7
Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.死亡率、发病率和风险因素在中国及其省份，1990-2017 年：2017 年全球疾病负担研究的系统分析。
Lancet. 2019 Sep 28;394(10204):1145-1158. doi: 10.1016/S0140-6736(19)30427-1. Epub 2019 Jun 24.
8
Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.全球、区域和国家卒中负担，1990-2016 年：2016 年全球疾病负担研究的系统分析。
Lancet Neurol. 2019 May;18(5):439-458. doi: 10.1016/S1474-4422(19)30034-1. Epub 2019 Mar 11.
9
PPAR𝛾 Gene and Atherosclerosis: Genetic Polymorphisms, Epigenetics and Therapeutic Implications.PPARγ基因与动脉粥样硬化：基因多态性、表观遗传学及治疗意义
Balkan J Med Genet. 2018 Oct 29;21(1):39-46. doi: 10.2478/bjmg-2018-0011. eCollection 2018 Jun.
10
Treatment with the PPARγ Agonist Pioglitazone in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem Cells in Rats.在缺血后早期阶段用 PPARγ 激动剂吡格列酮治疗通过激活固有和骨髓源性干细胞抑制大鼠的促炎反应并促进神经发生。
Transl Stroke Res. 2018 Jun;9(3):306-316. doi: 10.1007/s12975-017-0577-8. Epub 2017 Nov 6.