Chen F D, Hendry J H
Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.
Radiother Oncol. 1988 Feb;11(2):153-9. doi: 10.1016/0167-8140(88)90251-4.
The amount of residual injury in mouse tail skin, assessed by the decrease in re-irradiation dose for equal effect, was similar whether assessed using healing or colony endpoints (17-21% after single priming doses). There were tendencies towards an increased sensitivity of the colony-forming cells by a factor of about 2, and less residual injury after multifractionated priming doses. These observations are compatible with a lower alpha/beta ratio characterising the response to dose fractionation for residual injury than for the acute healing response.
通过同等效应下再照射剂量的降低来评估，小鼠尾部皮肤的残留损伤量，无论使用愈合终点还是集落终点进行评估，结果都是相似的（单次预照射剂量后为17 - 21%）。集落形成细胞的敏感性有增加约2倍的趋势，且多次分割预照射剂量后的残留损伤较少。这些观察结果与以下情况相符：与急性愈合反应相比，残留损伤对剂量分割反应的α/β比值较低。
