Kanno Ryoko, Koshizuka Tetsuo, Miyazaki Nozomu, Kobayashi Takahiro, Ishioka Ken, Ozaki Chiaki, Chiba Hideki, Suzutani Tatsuo
Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Department of Microbiology and Immunology, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Foods. 2021 Feb 1;10(2):291. doi: 10.3390/foods10020291.
Soybeans and fermented soy-derived foodstuffs contain many functional components and demonstrate various beneficial effects. In this report, we demonstrate the anti-fatty liver effect of a traditional fermented product made from soybeans and rice molded in and forming a common part of the Japanese diet. After acclimation for 2 weeks, male and female C57BL/6J mice were fed with a normal diet (ND), a high-fat diet (HFD), a HFD containing 5% (HFD+M), or a HFD containing 5% pre-fermented (HFD+PFM) for 20 weeks. Although mice in the HFD group developed typical fatty liver, the consumption of or PFM significantly ameliorated the progression of fatty liver in female mice. The liver weight and the average nonalcoholic fatty liver disease activity score (NAS) were significantly reduced in the HFD+M and HFD+PFM groups. In addition, leptin and resistin levels in the serum were decreased in the HFD+M and HFD+PFM groups. The progression of fatty liver was also prevented by the consumption of or PFM in male mice, although there were no decreases in NAS. Therefore, appears to be a potential food to prevent lifestyle-related diseases such as metabolic syndrome.
大豆及大豆发酵衍生食品含有多种功能成分，并具有多种有益功效。在本报告中，我们展示了一种由大豆和大米制成的传统发酵产品的抗脂肪肝作用，该产品是日本饮食的常见组成部分。适应2周后，将雄性和雌性C57BL/6J小鼠分别喂食正常饮食（ND）、高脂饮食（HFD）、含5% [具体物质未明确，此处用“[具体物质]”表示]的高脂饮食（HFD+M）或含5%预发酵[具体物质]的高脂饮食（HFD+PFM），持续20周。尽管高脂饮食组的小鼠出现了典型的脂肪肝，但食用[具体物质]或预发酵[具体物质]显著改善了雌性小鼠脂肪肝的进展。HFD+M组和HFD+PFM组的肝脏重量和平均非酒精性脂肪性肝病活动评分（NAS）显著降低。此外，HFD+M组和HFD+PFM组血清中的瘦素和抵抗素水平降低。在雄性小鼠中，食用[具体物质]或预发酵[具体物质]也预防了脂肪肝的进展，尽管NAS没有降低。因此，[具体物质]似乎是预防代谢综合征等生活方式相关疾病的潜在食物。
