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发酵大豆制品（肠内糖）摄入后异黄酮代谢物的营养动力学：去卵巢小鼠模型的研究。

Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice.

机构信息

Research Group of Metabolic Mechanism, Korea Food Research Institute, Seongnam, Republic of Korea.

Department of Food Biotechnology, Korea University of Science and Technology, Seongnam, Republic of Korea.

出版信息

Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700322.

DOI:10.1002/mnfr.201700322
PMID:28981201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6139428/
Abstract

SCOPE

Cheonggukjang (CGJ) is a soybean-based quick-fermented food popular in Korea that contains a variety of biologically active compounds including isoflavones and saponins. Isoflavone bioavailability may be important for the bone health of postmenopausal women; therefore, the aim of this study is to evaluate the influence of fermentation on the isoflavone metabolite nutrikinetic profile after single dose CGJ or unfermented soybean administration in ovariectomized (OVX) and sham mice.

METHODS AND RESULTS

We identify 34 isoflavone metabolites using UPLC-QTOF-MS and analyze their nutrikinetics at different time points (0.25, 0.5, 1, 2, 4, 8, 16, and 24 h) to understand their fermentation- and OVX-mediated time-dependent concentration changes. Nutrikinetics analysis shows that genistein, daidzein, genistein 4'-sulfate, dihydrodaidzein sulfate, equol 4'-sulfate, and equol-7-glucuronide are present at high concentrations in all groups based on area-under-the-curve analysis. OVX mice appear to show lower isoflavone bioavailability than mice in the sham group. CGJ enhances various isoflavone metabolite bioavailability including genistein, 3-hydroxygenistein, and equol 7-glucuronide, compared to the unfermented soybean-treated group. Among these metabolites, intact isoflavones, 3-hydroxygenistein, genistein 4'-sulfate, and equol 7-glucuronide promote osteoblastogenesis and inhibit osteoclast formation.

CONCLUSIONS

CGJ has good isoflavone bioavailability and may be beneficial for the bone health of postmenopausal women.

摘要

范围

葱酱（CGJ）是一种在韩国流行的大豆速发酵食品，含有多种生物活性化合物，包括异黄酮和皂苷。异黄酮的生物利用度可能对绝经后妇女的骨骼健康很重要；因此，本研究旨在评估发酵对单次 CGJ 或未发酵大豆给药后异黄酮代谢物营养动力学特征的影响在去卵巢（OVX）和假手术小鼠中。

方法和结果

我们使用 UPLC-QTOF-MS 鉴定了 34 种异黄酮代谢物，并分析了它们在不同时间点（0.25、0.5、1、2、4、8、16 和 24 h）的营养动力学，以了解它们的发酵和 OVX 介导的时间依赖性浓度变化。营养动力学分析表明，基于曲线下面积分析，金雀异黄素、大豆苷元、金雀异黄素 4'-硫酸盐、二氢大豆苷元硫酸盐、雌马酚 4'-硫酸盐和雌马酚-7-葡萄糖醛酸苷在所有组中均以高浓度存在。与假手术组相比，OVX 小鼠似乎表现出较低的异黄酮生物利用度。与未发酵大豆处理组相比，CGJ 增强了各种异黄酮代谢物的生物利用度，包括金雀异黄素、3-羟基金雀异黄素和雌马酚 7-葡萄糖醛酸苷。在这些代谢物中，完整的异黄酮、3-羟基金雀异黄素、金雀异黄素 4'-硫酸盐和雌马酚 7-葡萄糖醛酸苷可促进成骨细胞生成并抑制破骨细胞形成。

结论

CGJ 具有良好的异黄酮生物利用度，可能有益于绝经后妇女的骨骼健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/caa424eaed62/MNFR-61-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/9087ddf5e828/MNFR-61-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/a948e997c16b/MNFR-61-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/68600153a153/MNFR-61-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/caa424eaed62/MNFR-61-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/9087ddf5e828/MNFR-61-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/a948e997c16b/MNFR-61-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/68600153a153/MNFR-61-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/141f/6139428/caa424eaed62/MNFR-61-na-g004.jpg

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