Departamento de Ingeniería Química, Facultad de Ingeniería, Universidad de Santiago de Chile (USACH), Santiago 8330111, Chile.
Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Santiago 8330111, Chile.
Molecules. 2021 Feb 1;26(3):752. doi: 10.3390/molecules26030752.
Brassicaceae are an outstanding source of bioactive compounds such as ascorbic acid, polyphenols, essential minerals, isothiocyanates and their precursors, glucosinolates (GSL). Recently, GSL gained great attention because of the health promoting properties of their hydrolysis products: isothiocyanates. Among them, sulforaphane (SFN) became the most attractive one owing to its remarkable health-promoting properties. SFN may prevent different types of cancer and has the ability to improve hypertensive states, to prevent type 2 diabetes-induced cardiomyopathy, and to protect against gastric ulcer. SFN may also help in schizophrenia treatment, and recently it was proposed that SFN has potential to help those who struggle with obesity. The mechanism underlying the health-promoting effect of SFN relates to its indirect action at cellular level by inducing antioxidant and Phase II detoxifying enzymes through the activation of transcription nuclear factor (erythroid-derived 2)-like (Nrf2). The effect of SFN on immune response is generating scientific interest, because of its bioavailability, which is much higher than other phytochemicals, and its capacity to induce Nrf2 target genes. Clinical trials suggest that sulforaphane produces favorable results in cases where pharmaceutical products fail. This article provides a revision about the relationship between sulforaphane and immune response in different diseases. Special attention is given to clinical trials related with immune system disorders.
芸薹属植物是生物活性化合物的重要来源，如抗坏血酸、多酚、必需矿物质、异硫氰酸酯及其前体、硫代葡萄糖苷（GSL）。最近，由于其水解产物异硫氰酸酯具有促进健康的特性，GSL 引起了极大的关注。其中，萝卜硫素（SFN）因其显著的促进健康的特性而成为最具吸引力的一种。SFN 可能预防不同类型的癌症，并有能力改善高血压状态，预防 2 型糖尿病引起的心肌病，并防止胃溃疡。SFN 还可能有助于精神分裂症的治疗，最近有人提出 SFN 有潜力帮助那些肥胖的人。SFN 促进健康的作用机制与其通过激活核因子（红系衍生 2 样）（Nrf2）间接在细胞水平上诱导抗氧化和第二阶段解毒酶有关。SFN 对免疫反应的影响引起了科学界的兴趣，因为它的生物利用度比其他植物化学物质高得多，而且它能够诱导 Nrf2 靶基因。临床试验表明，在药物产品失败的情况下，萝卜硫素会产生有利的结果。本文综述了萝卜硫素与不同疾病中免疫反应的关系。特别关注与免疫系统紊乱相关的临床试验。
