Ferrada Luciano, Magdalena Rocío, Barahona María Jose, Ramírez Eder, Sanzana Cristian, Gutiérrez José, Nualart Francisco
Center for Advanced Microscopy CMA BIO BIO, Faculty of Biological Sciences, University of Concepcion, Concepción 4030000, Chile.
Laboratory of Neurobiology and Stem Cells NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepcion, Concepción 4030000, Chile.
Antioxidants (Basel). 2021 Feb 1;10(2):215. doi: 10.3390/antiox10020215.
Historically, vitamin C has been associated with many regulatory processes that involve specific signaling pathways. Among the most studied signaling pathways are those involved in the regulation of aging, differentiation, neurotransmission, proliferation, and cell death processes in cancer. This wide variety of regulatory effects is due to the fact that vitamin C has a dual mechanism of action. On the one hand, it regulates the expression of genes associated with proliferation (Ccnf and Ccnb1), differentiation (Sox-2 and Oct-4), and cell death (RIPK1 and Bcl-2). At the same time, vitamin C can act as a regulator of kinases, such as MAPK and p38, or by controlling the activation of the NF-kB pathway, generating chronic responses related to changes in gene expression or acute responses associated with the regulation of signal transduction processes. To date, data from the literature show a permanent increase in processes regulated by vitamin C. In this review, we critically examine how vitamin C regulates these different cellular programs in normal and tumor cells.
从历史上看，维生素C与许多涉及特定信号通路的调节过程相关。在研究最多的信号通路中，有那些参与调节衰老、分化、神经传递、增殖以及癌症中的细胞死亡过程的通路。这种广泛的调节作用归因于维生素C具有双重作用机制。一方面，它调节与增殖（Ccnf和Ccnb1）、分化（Sox-2和Oct-4）以及细胞死亡（RIPK1和Bcl-2）相关的基因表达。同时，维生素C可以作为激酶的调节剂，如MAPK和p38，或者通过控制NF-kB通路的激活，产生与基因表达变化相关的慢性反应或与信号转导过程调节相关的急性反应。迄今为止，文献数据表明维生素C调节的过程持续增加。在本综述中，我们批判性地研究了维生素C如何调节正常细胞和肿瘤细胞中的这些不同细胞程序。
