Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, 00-725 Warsaw, Poland.
Nutrients. 2022 Feb 25;14(5):979. doi: 10.3390/nu14050979.
Vitamin C has a number of acitvities that could contribute to its immune-modulating effects. The only question is whether we should provide ourselves with only the right level of it, or do we need much more during a pandemic? The possibility of reducing the incidence of viral diseases in a well-nourished population through the use of dietary supplements based on vitamin C is not supported in the literature. Despite this, the belief that an extra intake of vitamin C can increase the efficacy of the immune system is still popular and vitamin C is advertised as a remedy to prevent infectious disease. This article refers to the justification of the use of vitamin C in high doses as an anti-SARS-CoV-2 prophylaxis in healthy subjects. Does it make sense or not? As it turns out, any effects of vitamin C supplementation may be more prominent when the baseline vitamin C level is low, for example in physically active persons. People with hypovitaminosis C are more likely to respond to vitamin C administration. No studies regarding prevention of COVID-19 with high-dose vitamin C supplementation in healthy subjects were found.
维生素 C 具有多种活性，可能有助于其免疫调节作用。唯一的问题是，我们应该只提供适量的维生素 C，还是在大流行期间需要更多？通过使用基于维生素 C 的膳食补充剂来降低营养良好人群中病毒疾病的发病率，这在文献中并没有得到支持。尽管如此，人们仍然相信额外摄入维生素 C 可以提高免疫系统的功效，并且维生素 C 被宣传为预防传染病的药物。本文提到了使用大剂量维生素 C 作为健康受试者的抗 SARS-CoV-2 预防措施的合理性。这是否有意义？事实证明，当基础维生素 C 水平较低时，例如在身体活跃的人群中，维生素 C 补充的任何效果可能更为明显。维生素 C 缺乏症患者更有可能对维生素 C 治疗做出反应。没有发现关于在健康受试者中使用大剂量维生素 C 补充剂预防 COVID-19 的研究。
