Department of Cardiology, Peking University First Hospital, Beijing, People's Republic of China.
Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, People's Republic of China.
Nutr Neurosci. 2022 Jul;25(7):1524-1533. doi: 10.1080/1028415X.2021.1875299. Epub 2021 Feb 3.
Uncertainty remains regarding the association between the risk of stroke and plasma copper levels in population with copper mostly in normal range due to limited data. We examined the association between baseline plasma copper and risk of first stroke in Chinese community-dwelling population.
We conducted a nested case control study from 'H-type Hypertension and Stroke Prevention and Control Project'. A total of 1255 first stroke cases and 1255 controls matched for age, sex and study site were included in the analysis. Conditional logistic regression analyses were performed to evaluate the association between plasma copper and first stroke.
The overall mean of copper was 15.90 (2.66) μmol/L. In total, 94.26% participants' copper concentration was in the normal range by Mayo Clinic laboratory reference values. Smoothing curve showed that the associations of plasma copper with first stroke and its subtypes were linear. Each standard deviation (SD) increment of plasma copper was independently and positively associated with risk of first stroke [odds ratio (OR): 1.17, 95% confidence interval (CI): 1.07-1.28]. The multivariable ORs with 95% CIs for total stroke, ischemic stroke and hemorrhagic stroke in the highest versus the lowest quartile of plasma copper were 1.49 (1.16-1.90; -trend = 0.001), 1.46 (1.12-1.92; -trend = 0.004) and 2.05 (0.95-4.38; -trend = 0.050), respectively.
Baseline plasma copper was positively associated with risk of first ischemic stroke in an approximately linear fashion among Chinese community population (80.32% hypertensives), although their copper levels were mostly within the normal range according to current reference values. Our findings warrant additional investigation.
由于数据有限，对于铜处于正常范围内的人群中，血浆铜水平与中风风险之间的关联仍存在不确定性。我们研究了中国社区居民人群中基线血浆铜与首次中风风险之间的关系。
我们开展了一项来自“H 型高血压与脑卒中防控项目”的巢式病例对照研究。共纳入了 1255 例首发脑卒中病例和 1255 名年龄、性别和研究地点相匹配的对照者。采用条件 logistic 回归分析评估了血浆铜与首次中风之间的关系。
铜的总体平均值为 15.90(2.66)μmol/L。根据 Mayo 临床实验室参考值，共有 94.26%的参与者铜浓度处于正常范围。平滑曲线显示，血浆铜与首次中风及其亚型之间的关系呈线性。血浆铜每增加一个标准差（SD），与首次中风风险独立正相关[比值比（OR）：1.17，95%置信区间（CI）：1.07-1.28]。在最高四分位与最低四分位的血浆铜中，全因卒中、缺血性卒中和出血性卒中的多变量 OR 及其 95%CI 分别为 1.49（1.16-1.90；-趋势=0.001）、1.46（1.12-1.92；-趋势=0.004）和 2.05（0.95-4.38；-趋势=0.050）。
在中国社区人群（80.32%高血压患者）中，基线血浆铜与首次缺血性卒中风险呈近似线性正相关，尽管根据目前的参考值，他们的铜水平大多处于正常范围内。我们的研究结果值得进一步研究。
