Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei, People's Republic of China.
Hebei Key Laboratory of Critical Disease Mechanism and Intervention, Shijiazhuang, 050017, People's Republic of China.
Mol Neurobiol. 2024 Apr;61(4):2270-2282. doi: 10.1007/s12035-023-03714-z. Epub 2023 Oct 23.
The morbidity rate of ischemic stroke is increasing annually with the growing aging population in China. Astrocytes are ubiquitous glial cells in the brain and play a crucial role in supporting neuronal function and metabolism. Increasing evidence shows that the impairment or loss of astrocytes contributes to neuronal dysfunction during cerebral ischemic injury. The mitochondrion is increasingly recognized as a key player in regulating astrocyte function. Changes in astrocytic mitochondrial function appear to be closely linked to the homeostasis imbalance defects in glutamate metabolism, Ca regulation, fatty acid metabolism, reactive oxygen species, inflammation, and copper regulation. Here, we discuss the role of astrocytic mitochondria in the pathogenesis of brain ischemic injury and their potential as a therapeutic target.
在中国，人口老龄化的加剧导致缺血性中风的发病率逐年上升。星形胶质细胞是大脑中普遍存在的神经胶质细胞，在支持神经元功能和代谢方面发挥着关键作用。越来越多的证据表明，星形胶质细胞的损伤或缺失会导致脑缺血损伤时神经元功能障碍。线粒体越来越被认为是调节星形胶质细胞功能的关键因素。星形胶质细胞线粒体功能的变化似乎与谷氨酸代谢、Ca 调节、脂肪酸代谢、活性氧、炎症和铜调节的内稳态失衡缺陷密切相关。在这里，我们讨论了星形胶质细胞线粒体在脑缺血损伤发病机制中的作用及其作为治疗靶点的潜力。
