Yang Yan-Chang, Li Qiu-Yu, Chen Min-Jie, Zhang Li-Juan, Zhang Meng-Yao, Pan Yi-Cong, Ge Qian-Min, Shu Hui-Ye, Lin Qi, Shao Yi
Department of Ophthalmology, Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi, People's Republic of China.
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi, People's Republic of China.
Neuropsychiatr Dis Treat. 2021 Jan 28;17:251-260. doi: 10.2147/NDT.S292132. eCollection 2021.
The percent amplitude of fluctuation (PerAF) method was used to study the changes in neural activities and functions in specific brain regions of patients with a retinal detachment (RD).
In this study, we recruited 15 RD patients (nine males and six females) and 15 healthy controls (HCs) matched for gender, age, and weight. All participants were scanned with resting functional magnetic resonance imaging (rs-fMRI). The PerAF method was then used for data analysis to evaluate and detect changes in neural activity in relevant brain regions. Receiver operating characteristic (ROC) curve analysis was used to evaluate the two groups.
The PerAF signal values of the right fusiform gyrus and the left inferior temporal gyrus of RD patients were significantly higher than those of HCs. This may indicate changes in neural activity and function in the related brain regions. The anxiety and depression scores of hospital anxiety and depression scale (HADS) and the durations in RD patients were positively correlated with the PerAF values of the left inferior temporal gyrus.
In this study, we demonstrated that there were significant changes in the PerAF values in specific areas of the brain in patients with RD. The change of PerAF values represent the changes of BOLD signal intensity, which reflect the hyperactivity or weakening of specific brain regions in RD patients, which are helpful to predict the development and prognosis of RD patients, and play an important role in the early diagnosis of RD. In addition, according to the results, changes in neural activity in specific brain regions of RD patients increase the risk of brain dysfunction related diseases, which may help to understand the pathological mechanism of vision loss in RD patients.
采用波动百分比（PerAF）方法研究视网膜脱离（RD）患者特定脑区神经活动和功能的变化。
本研究招募了15例RD患者（9例男性，6例女性）和15名性别、年龄和体重相匹配的健康对照者（HCs）。所有参与者均接受静息功能磁共振成像（rs-fMRI）扫描。然后使用PerAF方法进行数据分析，以评估和检测相关脑区神经活动的变化。采用受试者工作特征（ROC）曲线分析对两组进行评估。
RD患者右侧梭状回和左侧颞下回的PerAF信号值显著高于HCs。这可能表明相关脑区神经活动和功能发生了变化。RD患者医院焦虑抑郁量表（HADS）的焦虑和抑郁评分及病程与左侧颞下回的PerAF值呈正相关。
在本研究中，我们证明了RD患者大脑特定区域的PerAF值存在显著变化。PerAF值的变化代表了血氧水平依赖（BOLD）信号强度的变化，反映了RD患者特定脑区的活动增强或减弱，这有助于预测RD患者的病情发展和预后，对RD的早期诊断具有重要作用。此外，根据结果，RD患者特定脑区神经活动的变化增加了脑功能障碍相关疾病的风险，这可能有助于理解RD患者视力丧失的病理机制。
