Ren Junyu, Yue Bei, Wang Hao, Zhang Beibei, Luo Xiaoping, Yu Zhilun, Zhang Jing, Ren Yijing, Mani Sridhar, Wang Zhengtao, Dou Wei
The MOE key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and the SATCM key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, China.
Department of Medicine and Genetics, Albert Einstein College of Medicine, The Bronx, NY, United States.
Front Physiol. 2021 Jan 18;11:577237. doi: 10.3389/fphys.2020.577237. eCollection 2020.
Acacetin, a natural dietary flavonoid abundantly found in acacia honey and citrus fruits, reportedly exerts several biological effects, such as anti-tumor, anti-inflammatory, and anti-oxidative effects. However, the effects of acacetin on intestinal inflammation remain unclear. We sought to investigate whether acacetin ameliorates inflammatory bowel disease (IBD) in mice with dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Our results suggest that acacetin alleviates the clinical symptoms of DSS-induced colitis, as determined by body weight loss, diarrhea, colon shortening, inflammatory infiltration, and histological injury. Further studies showed that acacetin remarkably inhibited both the macrophage inflammatory response and levels of inflammatory mediators in mice with colitis. In addition, some features of the gut microbiota were disordered in mice with DSS-induced colitis, as evidenced by a significant reduction in microbiota diversity and a marked shift in bacterial profiles. However, acacetin treatment improved this imbalance and restored gut microbiota to levels that were similar to those in normal mice. In conclusion, our work presents evidence that acacetin attenuates DSS-induced colitis in mice, at least in part, by inhibiting inflammation and regulating the intestinal microbiota.
刺槐素是一种天然膳食类黄酮，大量存在于刺槐蜂蜜和柑橘类水果中，据报道具有多种生物学效应，如抗肿瘤、抗炎和抗氧化作用。然而，刺槐素对肠道炎症的影响仍不清楚。我们试图研究刺槐素是否能改善葡聚糖硫酸钠（DSS）诱导的溃疡性结肠炎（UC）小鼠的炎症性肠病（IBD）。我们的结果表明，刺槐素可减轻DSS诱导的结肠炎的临床症状，这通过体重减轻、腹泻、结肠缩短、炎症浸润和组织学损伤来确定。进一步的研究表明，刺槐素可显著抑制结肠炎小鼠的巨噬细胞炎症反应和炎症介质水平。此外，DSS诱导的结肠炎小鼠的肠道微生物群的一些特征出现紊乱，表现为微生物群多样性显著降低和细菌谱明显改变。然而，刺槐素治疗改善了这种失衡，并使肠道微生物群恢复到与正常小鼠相似的水平。总之，我们的研究表明，刺槐素至少部分通过抑制炎症和调节肠道微生物群来减轻DSS诱导的小鼠结肠炎。
