Bantle Collin M, Hirst Warren D, Weihofen Andreas, Shlevkov Evgeny
Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA, United States.
Front Cell Dev Biol. 2021 Jan 7;8:608026. doi: 10.3389/fcell.2020.608026. eCollection 2020.
Mitochondrial dysfunction is a hallmark of Parkinson's disease (PD). Astrocytes are the most abundant glial cell type in the brain and are thought to play a pivotal role in the progression of PD. Emerging evidence suggests that many astrocytic functions, including glutamate metabolism, Ca signaling, fatty acid metabolism, antioxidant production, and inflammation are dependent on healthy mitochondria. Here, we review how mitochondrial dysfunction impacts astrocytes, highlighting translational gaps and opening new questions for therapeutic development.
线粒体功能障碍是帕金森病（PD）的一个标志。星形胶质细胞是大脑中最丰富的胶质细胞类型，被认为在PD的进展中起关键作用。新出现的证据表明，许多星形胶质细胞的功能，包括谷氨酸代谢、钙信号传导、脂肪酸代谢、抗氧化剂产生和炎症，都依赖于健康的线粒体。在这里，我们综述线粒体功能障碍如何影响星形胶质细胞，强调转化研究中的差距，并为治疗开发提出新问题。
