Lu Huizhi, Hua Yuejin
MOE Key Laboratory of Biosystems Homeostasis and Protection, Institute of Biophysics, College of Life Sciences, Zhejiang University, Hangzhou, China.
Front Cell Dev Biol. 2021 Jan 18;8:609714. doi: 10.3389/fcell.2020.609714. eCollection 2020.
Deoxyribonucleic acid (DNA) damage response (DDR) pathways are essential for maintaining the integrity of the genome when destabilized by various damaging events, such as ionizing radiation, ultraviolet light, chemical or oxidative stress, and DNA replication errors. The PprI-DdrO system is a newly identified pathway responsible for the DNA damage response in , in which PprI (also called IrrE) acts as a crucial component mediating the extreme resistance of these bacteria. This review describes studies about PprI sequence conservation, regulatory function, structural characteristics, biochemical activity, and hypothetical activation mechanisms as well as potential applications.
脱氧核糖核酸（DNA）损伤反应（DDR）途径对于在基因组因各种损伤事件（如电离辐射、紫外线、化学或氧化应激以及DNA复制错误）而不稳定时维持基因组的完整性至关重要。PprI-DdrO系统是新发现的负责DNA损伤反应的途径，其中PprI（也称为IrrE）是介导这些细菌极端抗性的关键成分。本文综述了关于PprI的序列保守性、调控功能、结构特征、生化活性、假设的激活机制以及潜在应用的研究。
