Chen Zijing, Tang Yuyue, Hua Yuejin, Zhao Ye
Institute of Biophysics, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang University, Hangzhou, Zhejiang, China.
Comput Struct Biotechnol J. 2020 Oct 7;18:2810-2817. doi: 10.1016/j.csbj.2020.09.036. eCollection 2020.
can survive under extreme conditions, including high doses of DNA damaging agents and ionizing radiation, desiccation, and oxidative stress. Both the efficient cellular DNA repair machinery and antioxidation systems contribute to the extreme resistance of this bacterium, making it an ideal organism for studying the cellular mechanisms of environmental adaptation. The number of stress-related proteins identified in this bacterium has mushroomed in the past two decades. The newly identified proteins reveal both commonalities and diversity of structure, mechanism, and function, which impact a wide range of cellular functions. Here, we review the unique and general structural features of these proteins and discuss how these studies improve our understanding of the environmental stress adaptation mechanisms of .
能够在极端条件下存活，包括高剂量的DNA损伤剂和电离辐射、干燥和氧化应激。高效的细胞DNA修复机制和抗氧化系统都有助于这种细菌的极端抗性，使其成为研究细胞环境适应机制的理想生物体。在过去二十年中，这种细菌中鉴定出的应激相关蛋白数量迅速增加。新鉴定出的蛋白质揭示了结构、机制和功能的共性与多样性，这些影响着广泛的细胞功能。在这里，我们综述这些蛋白质独特和一般的结构特征，并讨论这些研究如何增进我们对……环境应激适应机制的理解。
