Hemilä Harri, de Man Angelique M E
Department of Public Health, University of Helsinki, Helsinki, Finland.
Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Front Med (Lausanne). 2021 Jan 18;7:559811. doi: 10.3389/fmed.2020.559811. eCollection 2020.
In numerous animal studies, vitamin C has prevented and alleviated viral and bacterial infections. In a few dozen placebo-controlled trials with humans, vitamin C has shortened infections caused by respiratory viruses, which indicates that the vitamin can also influence viral infections in humans. In critically ill patients, plasma vitamin C levels are commonly very low. Gram doses of vitamin C are needed to increase the plasma vitamin C levels of critically ill patients to the levels of ordinary healthy people. A meta-analysis of 12 trials with 1,766 patients calculated that vitamin C reduced the length of ICU stay on average by 8%. Another meta-analysis found that vitamin C shortened the duration of mechanical ventilation in ICU patients. Two randomized placebo-controlled trials found statistically significant reduction in the mortality of sepsis patients. The effects of vitamin C on acute respiratory distress syndrome (ARDS) frequently complicating COVID-19 pneumonia should be considered. Vitamin C is a safe and inexpensive essential nutrient.
在众多动物研究中，维生素C预防并减轻了病毒和细菌感染。在几十项针对人类的安慰剂对照试验中，维生素C缩短了由呼吸道病毒引起的感染病程，这表明该维生素也能影响人类的病毒感染。在重症患者中，血浆维生素C水平通常非常低。需要大剂量的维生素C才能将重症患者的血浆维生素C水平提高到普通健康人的水平。一项对12项试验、1766名患者的荟萃分析计算得出，维生素C平均缩短了8%的重症监护病房（ICU）住院时间。另一项荟萃分析发现，维生素C缩短了ICU患者机械通气的持续时间。两项随机安慰剂对照试验发现，败血症患者的死亡率有统计学意义的降低。应考虑维生素C对经常并发于新型冠状病毒肺炎的急性呼吸窘迫综合征（ARDS）的影响。维生素C是一种安全且廉价的必需营养素。
