Cheng Chak Kwong, Wang Chenguang, Shang Wenbin, Lau Chi Wai, Luo Jiang-Yun, Wang Li, Huang Yu
School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China.
Heart and Vascular Institute and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
Biochem Biophys Rep. 2021 Jan 22;25:100921. doi: 10.1016/j.bbrep.2021.100921. eCollection 2021 Mar.
Hyperhomocysteinemia (HHcy) is considered as a risk factor for several complications, including cardiovascular and neurological disorders. A high methionine low folate (HMLF) diet chronically causes HHcy by accumulating homocysteine in the systemic circulation. Elevated Hcy level is also associated with the incidence of diabetes mellitus. However, very few studies focus on the impact of HMLF diet on glucose homeostasis, and that on gut microbiome profile. HHcy was induced by feeding C57BL/6 mice a HMLF diet for 8 weeks. The HMLF diet feeding resulted in a progressive body weight loss, and development of slight glucose intolerance and insulin resistance in HHcy mice. Notably, the HMLF diet alters the gut microbiome profile and increases the relative abundance of family of bacteria in HHcy mice. These findings provide new insights into the roles of dysregulated glucose homeostasis and gut flora in the pathogenesis of HHcy-related complications.
高同型半胱氨酸血症（HHcy）被认为是包括心血管和神经疾病在内的多种并发症的危险因素。高蛋氨酸低叶酸（HMLF）饮食通过在体循环中积累同型半胱氨酸而长期导致HHcy。同型半胱氨酸水平升高也与糖尿病的发病率有关。然而，很少有研究关注HMLF饮食对葡萄糖稳态的影响以及对肠道微生物群谱的影响。通过给C57BL/6小鼠喂食HMLF饮食8周来诱导HHcy。HMLF饮食喂养导致体重逐渐减轻，并在HHcy小鼠中出现轻微的葡萄糖不耐受和胰岛素抵抗。值得注意的是，HMLF饮食改变了肠道微生物群谱，并增加了HHcy小鼠中细菌家族的相对丰度。这些发现为葡萄糖稳态失调和肠道菌群在HHcy相关并发症发病机制中的作用提供了新的见解。
