National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Sydney, NSW.
Northern Clinical School, University of Sydney, Sydney, NSW.
Med J Aust. 2021 Mar;214(4):179-185. doi: 10.5694/mja2.50940. Epub 2021 Feb 3.
To estimate SARS-CoV-2-specific antibody seroprevalence after the first epidemic wave of coronavirus disease 2019 (COVID-19) in Sydney.
SETTING, PARTICIPANTS: People of any age who had provided blood for testing at selected diagnostic pathology services (general pathology); pregnant women aged 20-39 years who had received routine antenatal screening; and Australian Red Cross Lifeblood plasmapheresis donors aged 20-69 years.
Cross-sectional study; testing of de-identified residual blood specimens collected during 20 April - 2 June 2020.
Estimated proportions of people seropositive for anti-SARS-CoV-2-specific IgG, adjusted for test sensitivity and specificity.
Thirty-eight of 5339 specimens were IgG-positive (general pathology, 19 of 3231; antenatal screening, 7 of 560; plasmapheresis donors, 12 of 1548); there were no clear patterns by age group, sex, or location of residence. Adjusted estimated seroprevalence among people who had had general pathology blood tests (all ages) was 0.15% (95% credible interval [CrI], 0.04-0.41%), and 0.29% (95% CrI, 0.04-0.75%) for plasmapheresis donors (20-69 years). Among 20-39-year-old people, the age group common to all three collection groups, adjusted estimated seroprevalence was 0.24% (95% CrI, 0.04-0.80%) for the general pathology group, 0.79% (95% CrI, 0.04-1.88%) for the antenatal screening group, and 0.69% (95% CrI, 0.04-1.59%) for plasmapheresis donors.
Estimated SARS-CoV-2 seroprevalence was below 1%, indicating that community transmission was low during the first COVID-19 epidemic wave in Sydney. These findings suggest that early control of the spread of COVID-19 was successful, but efforts to reduce further transmission remain important.
估计 2019 年冠状病毒病（COVID-19）第一波疫情后悉尼地区人群中针对 SARS-CoV-2 的特异性抗体血清流行率。
地点、参与者：在选定的诊断病理学服务机构（常规病理学）接受检测的任何年龄的人群；年龄在 20-39 岁之间接受常规产前筛查的孕妇；年龄在 20-69 岁之间的澳大利亚红十字会生命血库血浆捐献者。
横断面研究；检测 2020 年 4 月 20 日至 6 月 2 日期间采集的剩余血液标本。
抗 SARS-CoV-2 特异性 IgG 血清阳性的估计比例，调整了检测敏感性和特异性。
38 份标本 IgG 阳性（常规病理学检测 19 份/3231 份，产前筛查 7 份/560 份，血浆捐献者 12 份/1548 份）；按年龄组、性别或居住地无明显模式。调整后的常规病理学检测人群（所有年龄）血清流行率估计值为 0.15%（95%可信区间 [CrI]，0.04-0.41%），血浆捐献者（20-69 岁）为 0.29%（95% CrI，0.04-0.75%）。在 20-39 岁人群中，即所有三个采集组共同的年龄组，常规病理学组血清流行率估计值为 0.24%（95% CrI，0.04-0.80%），产前筛查组为 0.79%（95% CrI，0.04-1.88%），血浆捐献者组为 0.69%（95% CrI，0.04-1.59%）。
估计的 SARS-CoV-2 血清流行率低于 1%，表明悉尼地区第一波 COVID-19 疫情期间社区传播水平较低。这些发现表明 COVID-19 的早期传播得到了成功控制，但减少进一步传播的努力仍然很重要。
