从菌株 Sm4-1986 中分离得到的化学成分。

Chemical constituents from the strain Sm4-1986.

机构信息

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou China.

出版信息

Nat Prod Res. 2022 Jul;36(14):3681-3688. doi: 10.1080/14786419.2021.1881095. Epub 2021 Feb 4.

DOI:10.1080/14786419.2021.1881095

PMID:33538196

Abstract

Three new compounds, including 6-methoxy-3,4,5,7-tetramethylisochromane-3,8-diol (), 3,4,5,7-tetramethylisochromane-3,6,8-triol (), streptimidone derivative (), along with ten known compounds (-) were isolated from the strain Sm4-1986. Their chemical structures were established based on the information from UV, IR, NMR (H NMR, C NMR, H-H COSY, HSQC, HMBC, NOESY), and mass spectroscopic. Moreover, all the isolated new compounds were evaluated for antibacterial activities (. , and methicillin-resistant ) and their cytotoxicities against MCF-7, A549, Hela tumor cell lines and Marc-145 normal cell line.

摘要

从菌株 Sm4-1986 中分离得到了三个新化合物，包括 6-甲氧基-3,4,5,7-四甲基异苯并二氢吡喃-3,8-二醇 ()、3,4,5,7-四甲基异苯并二氢吡喃-3,6,8-三醇 ()、链霉菌素衍生物 ()，以及十个已知化合物 (-)。根据 UV、IR、NMR (H NMR、C NMR、H-H COSY、HSQC、HMBC、NOESY) 和质谱等信息确定了它们的化学结构。此外，还评估了所有分离得到的新化合物的抗菌活性（对、和耐甲氧西林金黄色葡萄球菌）以及对 MCF-7、A549、Hela 肿瘤细胞系和 Marc-145 正常细胞系的细胞毒性。