从柬埔寨龙血树的龙血中提取的具有细胞毒性和抗菌作用的类黄酮。
Cytotoxic and antibacterial flavonoids from dragon's blood of Dracaena cambodiana.
机构信息
Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P. R. China.
出版信息
Planta Med. 2011 Dec;77(18):2053-6. doi: 10.1055/s-0031-1280086. Epub 2011 Jul 28.
Chemical studies on the constituents from the dragon's blood of Dracaena cambodiana led to the discovery of three new flavonoid derivatives (1- 3) and six known compounds (4- 9). The structures of the three new compounds were elucidated by NMR and MS spectroscopic analyses. All compounds were evaluated for their growth inhibitory activity against human cell lines K-562, SMMC-7721, and SGC-7901, as well as antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). As a result, compounds 1, 2, 5, 7, and 9 showed cytotoxicity against K-562, SMMC-7721, and SGC-7901 cell lines. All these compounds were observed to exhibit antibacterial activities against S. aureus, and compounds 1- 4, 6, 8, and 9 were observed to exhibit antibacterial activity against MRSA.
从柬埔寨龙血竭中分离得到的化学成分的研究导致了三个新的类黄酮衍生物（1-3）和六个已知化合物（4-9）的发现。通过 NMR 和 MS 光谱分析阐明了这三个新化合物的结构。所有化合物都进行了对人细胞系 K-562、SMMC-7721 和 SGC-7901 的生长抑制活性以及对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性的评估。结果表明，化合物 1、2、5、7 和 9 对 K-562、SMMC-7721 和 SGC-7901 细胞系具有细胞毒性。所有这些化合物均表现出对金黄色葡萄球菌的抗菌活性，化合物 1-4、6、8 和 9 对 MRSA 也表现出抗菌活性。
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