Lorenzo-Zúñiga Vicente, Bustamante-Balén Marco, Pons-Beltrán Vicente
Endoscopy Unit, Department of Gastroenterology, Hospital Universitari i Politècnic La Fe, Valencia 46026, Spain.
Digestive Diseases Department, La Fe Polytechnic University Hospital, Valencia 46026, Spain.
World J Gastroenterol. 2021 Apr 21;27(15):1563-1568. doi: 10.3748/wjg.v27.i15.1563.
Endoscopic removal of large (≥ 20 mm) non-pedunculated colorectal lesions (LNPCLs) may result in major adverse events, such as delayed bleeding (DB) and delayed perforation (DP), despite closure of the mucosal defects with clips. Topical application of a coverage agent refers to the creation of a shield with a biocompatible medical device (tissue or hydrogel) with proven bioactive properties. Coverage of the eschar after endoscopic resection provides shielding protection to prevent delayed complications. The aim of the present review was to systematically collect and review the currently available literature regarding the prevention of DB and DP with coverage agents after endoscopic mucosal resection or endoscopic submucosal dissection of LNPCLs.
内镜下切除大的（≥20毫米）无蒂结直肠病变（LNPCLs）可能会导致严重不良事件，如延迟出血（DB）和延迟穿孔（DP），尽管已用夹子封闭黏膜缺损。局部应用覆盖剂是指用具有经证实的生物活性特性的生物相容性医疗设备（组织或水凝胶）创建一个屏障。内镜切除后对焦痂进行覆盖可提供屏蔽保护以预防延迟性并发症。本综述的目的是系统收集和回顾目前关于在内镜黏膜切除术或内镜黏膜下剥离术切除LNPCLs后使用覆盖剂预防DB和DP的现有文献。
