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蛹虫草对TNFα/IFNγ刺激的HaCaT细胞及实验性诱导的小鼠特应性皮炎的抗特应性皮炎特性

Anti-atopic dermatitis properties of Cordyceps militaris on TNFα/IFNγ-stimulated HaCaT cells and experimentally induced atopic dermatitis in mice.

作者信息

Choi Eun-Ju, Park Bohyeon, Lee Joohyung, Kim Jooyoung

机构信息

Department of Physical Education, Daegu Catholic University, Gyeongsan, Republic of Korea.

Department of Sport, Health and Rehabilitation, Kookmin University, Seoul, Republic of Korea.

出版信息

Phys Act Nutr. 2020 Dec;24(4):7-14. doi: 10.20463/pan.2020.0022. Epub 2020 Dec 31.

DOI:10.20463/pan.2020.0022
PMID:33539689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7931639/
Abstract

PURPOSE

This study evaluated the anti-atopic dermatitis (AD) properties of Cordyceps militaris (CM) aqueous extract in keratinocytes in vitro and in vivo. We investigated the nutraceutical composition of the CM extract, including its protein, carbohydrate, and selected phytochemical content.

METHODS

The expression of pathogenic cytokines in keratinocytes was assayed using an in vitro model. The CM extract downregulated extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 kinase expression in TNFα/IFNγ-stimulated HaCaT cells. We also established an in vivo AD model by repeatedly exposing the ears of mice to local Dermatophagoides farinae extract (DFE; house dust mite extract) and 2,4-dinitrochlorobenzene (DNCB). The epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured following a 4-week oral administration of the CM extract.

RESULTS

Histopathological examination showed reduced epidermal/dermal thickness and mast cell infiltration in mouse ears. The CM extract also suppressed serum immunoglobulin levels and gene expression of T helper (Th)1/Th2 cytokines in mouse ear tissue.

CONCLUSION

These results suggest that the CM extract may be useful for the treatment of AD-like skin lesions.

摘要

目的

本研究评估了蛹虫草（CM）水提取物在体外和体内角质形成细胞中的抗特应性皮炎（AD）特性。我们研究了CM提取物的营养成分，包括其蛋白质、碳水化合物和选定的植物化学成分。

方法

使用体外模型检测角质形成细胞中致病细胞因子的表达。CM提取物下调了TNFα/IFNγ刺激的HaCaT细胞中细胞外信号调节激酶1/2（ERK1/2）和p38激酶的表达。我们还通过将小鼠耳朵反复暴露于局部粉尘螨提取物（DFE）和2,4-二硝基氯苯（DNCB）建立了体内AD模型。在口服CM提取物4周后，测量表皮和真皮耳部厚度、肥大细胞浸润和血清免疫球蛋白水平。

结果

组织病理学检查显示小鼠耳部表皮/真皮厚度和肥大细胞浸润减少。CM提取物还抑制了小鼠耳部组织中的血清免疫球蛋白水平和辅助性T细胞（Th）1/Th2细胞因子的基因表达。

结论

这些结果表明，CM提取物可能对治疗类AD皮肤病变有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/ca32e35efaf4/pan-2020-0022f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/c6a34831cbe3/pan-2020-0022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/f021eb244371/pan-2020-0022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/75c63cc90464/pan-2020-0022f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/e29cffc43f79/pan-2020-0022f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/ca32e35efaf4/pan-2020-0022f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/c6a34831cbe3/pan-2020-0022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/f021eb244371/pan-2020-0022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/75c63cc90464/pan-2020-0022f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/e29cffc43f79/pan-2020-0022f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/7931639/ca32e35efaf4/pan-2020-0022f5.jpg

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