Kawamoto T, Hobara T, Aoki T, Kobayashi H, Iwamoto S, Sakai T, Takano T, Miyazaki Y, Imamura A, Ogino K
Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan.
Toxicol Lett. 1988 Mar;40(3):225-31. doi: 10.1016/0378-4274(88)90045-8.
The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.
在无循环、无血红蛋白的肝脏灌注系统中研究了水合氯醛（CH）在缺氧条件下的代谢情况。缺氧肝脏对CH的摄取量降至供氧肝脏的约80%。CH还原为三氯乙醇（TCE）增加，而CH氧化为三氯乙酸（TCA）减少。TCE/TCA比值增加；然而，三氯化合物总量，即TCE和TCA，并未因缺氧而发生显著改变。尽管注入供氧肝脏的CH中约14%转变为TCE或TCA以外的物质，但在缺氧肝脏中未知部分所占比例非常小。缺氧肝脏对CH摄取的减少被认为等同于未知代谢产物的减少。缺氧条件下的TCE/TCA比值也会因丙酮酸或乳酸的注入而改变。
