三氯乙烯及其代谢产物在灌注肝脏中的代谢

The metabolism of trichloroethylene and its metabolites in the perfused liver.

作者信息

Kawamoto T, Hobara T, Kobayashi H, Iwamoto S, Sakai T, Imamura A, Koshiro A

出版信息

J Toxicol Sci. 1987 May;12(2):87-96. doi: 10.2131/jts.12.87.

DOI:10.2131/jts.12.87

Abstract

The metabolism of trichloroethylene (TRI) and its metabolites, chloral hydrate (CH), trichloroethanol (free-TCE) and trichloroacetic acid (TCA), were examined in the isolated perfused rat liver, to clarify the role of the liver in the metabolism of TRI. TRI was rapidly converted to TCE and TCA by the perfused liver. TCA was produced from TRI about 2.5 times greater than was total-TCE. CH was metabolized to TCE and TCA immediately. TCA was also a dominant metabolite of CH over total-TCE. TCE(free type) was speedily conjugated by the liver. A portion of TCE was converted to TCA. Less than 10% of these metabolites produced by the liver were excreted into the bile. Most of them appeared in the perfusate.

摘要

在离体灌注大鼠肝脏中研究了三氯乙烯（TRI）及其代谢产物水合氯醛（CH）、三氯乙醇（游离TCE）和三氯乙酸（TCA）的代谢，以阐明肝脏在TRI代谢中的作用。TRI被灌注肝脏迅速转化为TCE和TCA。TRI生成TCA的量约为总TCE的2.5倍。CH立即代谢为TCE和TCA。相对于总TCE，TCA也是CH的主要代谢产物。肝脏能迅速使TCE（游离型）结合。一部分TCE转化为TCA。肝脏产生的这些代谢产物中不到10%排泄到胆汁中。它们大多出现在灌注液中。