四氯化碳诱导肝损伤大鼠水合氯醛代谢的改变。

Alteration of chloral hydrate metabolism in rats with carbon tetrachloride-induced liver damage.

作者信息

Kawamoto T, Hobara T, Kobayashi H, Iwamoto S, Sakai T, Ogino K

出版信息

Toxicol Lett. 1987 Aug;37(3):263-8. doi: 10.1016/0378-4274(87)90141-x.

Abstract

The metabolism of chloral hydrate (CH) was investigated in the isolated perfused rat liver system. The experiments were performed on rats that were administered carbon tetrachloride (CCl4) subcutaneously for 15 weeks to induce chronic liver damage and on untreated rats. Clearance of CH from the perfusion system was lower in damaged liver than in control liver. In both groups, 50-70% of the added CH was excreted into perfusate as trichloroethanol (TCE) and trichloroacetic acid (TCA) within 120 min. The TCE/TCA ratio was 1:1.3 in the control group compared to 2:1 in the damaged liver group. The findings suggest that CH metabolism in the liver is affected by chronic damage.

摘要

在离体灌注大鼠肝脏系统中研究了水合氯醛（CH）的代谢。实验在皮下注射四氯化碳（CCl4）15周以诱导慢性肝损伤的大鼠和未处理的大鼠身上进行。受损肝脏对灌注系统中CH的清除率低于对照肝脏。在两组中，添加的CH在120分钟内有50 - 70%以三氯乙醇（TCE）和三氯乙酸（TCA）的形式排泄到灌注液中。对照组的TCE/TCA比值为1:1.3，而受损肝脏组为2:1。这些发现表明肝脏中的CH代谢受慢性损伤影响。