Cuccato Matteo, Rubiola Selene, Giannuzzi Diana, Grego Elena, Pregel Paola, Divari Sara, Cannizzo Francesca Tiziana
Department of Veterinary Science, University of Turin, Grugliasco, 10095 Turin, Italy.
Department of Agronomy, Food, Natural Resources, Animals and Environment, University of Padua, 35020 Legnaro, Italy.
Antibiotics (Basel). 2021 Feb 2;10(2):146. doi: 10.3390/antibiotics10020146.
In poultry production, gut microbiota (GM) plays a pivotal role and influences different host functions related to the efficiency of production performances. Antimicrobial (AM) use is one of the main factors affecting GM composition and functions. Although several studies have focused their attention on the role of AMs as growth promoters in the modulation of GM in broilers, the consequences of higher AM concentrations administered during prophylactic treatments need to be better elucidated. For this purpose, 16S rRNA gene sequencing was performed to evaluate the impact of different prophylactic AM protocols on the composition and diversity of the broiler GM. Diversity analysis has shown that AM treatment significantly affects alpha diversity in ileum and beta diversity in both ileum and caecum. In ileal samples, the family has been shown to be particularly affected by AM treatments. AMs have been demonstrated to affect GM composition in broiler. These findings indicate that withdrawal periods were not enough for the restoral of the original GM. Further studies are needed for a better elucidation of the negative effects caused by an altered GM in broilers.
在家禽生产中，肠道微生物群（GM）起着关键作用，并影响与生产性能效率相关的不同宿主功能。抗菌药物（AM）的使用是影响GM组成和功能的主要因素之一。尽管有几项研究关注了AM作为生长促进剂在调节肉鸡GM中的作用，但预防性治疗期间施用较高AM浓度的后果仍需进一步阐明。为此，进行了16S rRNA基因测序，以评估不同预防性AM方案对肉鸡GM组成和多样性的影响。多样性分析表明，AM处理显著影响回肠中的α多样性以及回肠和盲肠中的β多样性。在回肠样本中，该菌属已被证明特别受AM处理的影响。AM已被证明会影响肉鸡的GM组成。这些发现表明，停药期不足以恢复原始的GM。需要进一步研究，以更好地阐明肉鸡GM改变所造成的负面影响。
