Li Ximei, Li Jiawei, Yuan Haotian, Chen Yan, Li Shuaibing, Jiang Susu, Zha Xi Yingpai, Zhang Guohua, Lu Jianxiong
College of Life Science and Engineering, Northwest Minzu University, Lanzhou, China.
Department of Animal Science and Technology, Gansu Agriculture Technology College, Lanzhou, China.
Front Vet Sci. 2024 Jul 18;11:1436807. doi: 10.3389/fvets.2024.1436807. eCollection 2024.
Intestinal microbiota community is an important factor affecting the nutritional and health status of poultry, and its balance is crucial for improving the overall health of poultry. The study aimed to investigate the effect of dietary supplementation with extract (GUE), (Lac) and their combination (GL) on growth performance and intestinal health in broilers in an 84-day feeding experiment. Supplementary 0.1% GUE and 4.5×10 CFU/g Lac significantly increased average daily gain (ADG), and GL (0.1% GUE and 4.5×10 CFU/g Lac) increased ADG and average daily feed intake (ADFI), and decreased feed conversion rate (FCR) in broilers aged 29 to 84 d and 1 to 84 d. Dietary GUE, Lac and GL increased the superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity and decreased Malondialdehyde (MDA) content in the jejunum mucosa of broilers, and increased secretory IgA (sIgA) content in broilers at 84 d. Moreover, GUE, Lac and GL increased cecal microbial richness and diversity, and modulated microbial community composition. Both GUE and Lac reduced the harmful bacteria , , and at 28 d and , , and at 84 d, while Lac and GL increased beneficial bacteria and at 28 d. Compared with individual supplementation, GL markedly increased the SOD activity and the sIgA content, and reduced and . In conclusion, GUE and as feed additives benefit growth performance and intestinal health, and their combined use shows an even more positive effect in broilers.
肠道微生物群落是影响家禽营养和健康状况的重要因素，其平衡对于提高家禽的整体健康至关重要。本研究旨在通过一项为期84天的饲养实验，探讨日粮中添加胍提取物（GUE）、乳糖（Lac）及其组合（GL）对肉鸡生长性能和肠道健康的影响。补充0.1% GUE和4.5×10 CFU/g Lac显著提高了29至84日龄和1至84日龄肉鸡的平均日增重（ADG），GL（0.1% GUE和4.5×10 CFU/g Lac）提高了ADG和平均日采食量（ADFI），并降低了饲料转化率（FCR）。日粮中的GUE、Lac和GL提高了肉鸡空肠黏膜中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）的活性，降低了丙二醛（MDA）含量，并提高了84日龄肉鸡的分泌型IgA（sIgA）含量。此外，GUE、Lac和GL增加了盲肠微生物的丰富度和多样性，并调节了微生物群落组成。GUE和Lac在28日龄时均减少了有害菌 、 和 ，在84日龄时减少了 、 和 ，而Lac和GL在28日龄时增加了有益菌 和 。与单独添加相比，GL显著提高了SOD活性和sIgA含量，并降低了 和 . 总之，GUE和Lac作为饲料添加剂有利于生长性能和肠道健康，它们的联合使用对肉鸡表现出更积极的效果。
