Innovation and Scientific Affairs, Fytexia, 34350 Vendres, France.
Research Center for High Performance Sport, Catholic University of Murcia, 30107 Murcia, Spain.
Nutrients. 2021 Feb 2;13(2):492. doi: 10.3390/nu13020492.
Overweight and obesity adversely affect health-related quality of life (HRQOL) through day-to-day impairments of both mental and physical functioning. It is assumed that polyphenols within the Mediterranean diet may contribute to improving HRQOL. This investigation aimed at studying the effects of a polyphenol-rich ingredient on HRQOL in overweight and obese but otherwise healthy individuals. A randomized, double-blind, placebo-controlled study including 72 volunteers was conducted. Subjects were randomly assigned to receive for a 16-week period either 900 mg/day of the supplement or a placebo. Dietary recommendations were individually determined and intakes were recorded. Daily physical mobility was also monitored. Improvement of HRQOL was set as the primary outcome and assessed at baseline and at the end of the investigation using the Short-Form 36 (SF-36) health survey. Body composition was analyzed using dual-energy X-ray absorptiometry (DXA). Physical activity was calculated using the International Physical Activity Questionnaire (IPAQ). After 16 weeks, despite there being no adherence to the Mediterranean Diet Serving Score (MDSS), supplemented individuals experienced significant HRQOL improvement (+5.3%; = 0.001), including enhanced perceived physical (+11.2%; = 0.002) and mental health (+4.1%; = 0.021) components, with bodily pain, vitality, and general health being the greatest contributors. Body fat mass significantly decreased (-1.2 kg; = 0.033), mainly within the trunk area (-1.0 kg; = 0.002). Engagement in physical activity significantly increased (+1308 Met-min (Metabolic Equivalent Task minutes)/week; = 0.050). Hence, chronic supplementation with nutritional diversity and dosing of a Mediterranean diet-inspired, polyphenol-rich ingredient resulted in significant amelioration in both perceived physical and mental health, concomitant with the improvement of body composition, in healthy subjects with excessive adiposity.
超重和肥胖通过日常对精神和身体功能的损害对健康相关生活质量（HRQOL）产生不利影响。据认为，地中海饮食中的多酚可能有助于改善 HRQOL。本研究旨在研究富含多酚的成分对超重和肥胖但其他健康个体 HRQOL 的影响。进行了一项随机、双盲、安慰剂对照研究，纳入了 72 名志愿者。受试者被随机分配接受为期 16 周的 900mg/天的补充剂或安慰剂。单独确定了饮食建议，并记录了摄入量。还监测了日常身体活动。改善 HRQOL 被设定为主要结局，并使用简短形式 36 项健康调查（SF-36）在基线和研究结束时进行评估。使用双能 X 射线吸收法（DXA）分析身体成分。使用国际体力活动问卷（IPAQ）计算体力活动。经过 16 周，尽管没有遵循地中海饮食服务评分（MDSS），补充组的 HRQOL 显著改善（+5.3%； = 0.001），包括感知身体（+11.2%； = 0.002）和心理健康（+4.1%； = 0.021）的改善，身体疼痛、活力和一般健康状况是最大的贡献者。体脂肪量显著减少（-1.2kg； = 0.033），主要是在躯干区域（-1.0kg； = 0.002）。体力活动的参与显著增加（+1308 Met-min（代谢当量任务分钟）/周； = 0.050）。因此，长期补充营养多样性和剂量的地中海饮食启发的富含多酚的成分可显著改善健康超重个体的身体和心理健康，同时改善身体成分。
