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本文引用的文献

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[Clinical research on sleep quality in patients with tinnitus].[耳鸣患者睡眠质量的临床研究]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Oct;33(10):961-965. doi: 10.13201/j.issn.1001-1781.2019.10.015.
2
Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms.慢性耳鸣与边缘系统:重新评估痛苦和情感症状的大脑结构效应。
Neuroimage Clin. 2019;24:101976. doi: 10.1016/j.nicl.2019.101976. Epub 2019 Aug 7.
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Maladaptive plasticity in tinnitus--triggers, mechanisms and treatment.耳鸣中的适应性不良可塑性——触发因素、机制与治疗
Nat Rev Neurol. 2016 Mar;12(3):150-60. doi: 10.1038/nrneurol.2016.12. Epub 2016 Feb 12.
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The effect of insomnia on tinnitus.失眠对耳鸣的影响。
Ann Otol Rhinol Laryngol. 2014 Oct;123(10):696-700. doi: 10.1177/0003489414532779. Epub 2014 May 9.
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Sleep and emotions: bidirectional links and underlying mechanisms.睡眠与情绪:双向关联及其潜在机制。
Int J Psychophysiol. 2013 Aug;89(2):218-28. doi: 10.1016/j.ijpsycho.2013.05.010. Epub 2013 May 24.
6
Tinnitus and insomnia: is hyperarousal the common denominator?耳鸣与失眠:过度唤醒是共同的特征吗?
Sleep Med Rev. 2013 Feb;17(1):65-74. doi: 10.1016/j.smrv.2012.04.003. Epub 2012 Jun 30.
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[Chronic tinnitus: a grading management mode study].
Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):114-6.

经皮迷走神经刺激治疗慢性耳鸣的疗效

[Efficacy of percutaneous vagal stimulation in the treatment of chronic tinnitus].

作者信息

Zeng Xiangli, Zheng Ke, Cen Jintian, Wu Shixin, Li Zhicheng, Yin Gendi, Ke Zhuoli, Wu Huiqing

机构信息

Department of Otolaryngology,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,510630,China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb;35(2):105-108. doi: 10.13201/j.issn.2096-7993.2021.02.003.

DOI:10.13201/j.issn.2096-7993.2021.02.003
PMID:33540988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10127876/
Abstract

The aim of this study is to investigate the efficacy of transcutaneous vagus nerve stimulation(taVNS) in the treatment of chronic tinnitus. taVNS was used to treat chronic decompensated tinnitus, 10 days as a course of treatment. Record and analyze the improvement of the patient's subjective symptoms during treatment. The THI, PSQI and DASS-21 scores were performed at 10 days, 3 months and 6 months after treatment. The improvement of tinnitus in taVNS group and control group at the above recorded time points was compared, and the THI score of taVNS group was compared before and after treatment. ① During the taVNS treatment, 93.65% of the patients achieved improvement in subjective symptoms, and 28.6% of the patients voluntarily accepted the second course of taVNS treatment; ② The sleep improvement was optimal when the treatment was 10 days, and some patients had poor sleep status after 3 or 6 months; ③ The anxiety of taVNS group was improved during and after treatment, and the best effect time was 3 months and 6 months after treatment; ④ There was no significant difference in THI score between the two groups, but there was significant improvement in taVNS group at 3 months and 6 months after treatment. taVNS treatment can significantly improve the sleep disorder, anxiety disorder and tinnitus disturbance of tinnitus patients, and the curative effect is good after 3 months and 6 months of prevention.

摘要

本研究旨在探讨经皮迷走神经刺激(taVNS)治疗慢性耳鸣的疗效。采用taVNS治疗慢性失代偿性耳鸣,10天为一个疗程。记录并分析治疗期间患者主观症状的改善情况。在治疗后10天、3个月和6个月进行耳鸣残疾指数(THI)、匹兹堡睡眠质量指数(PSQI)和抑郁焦虑压力量表-21(DASS-21)评分。比较taVNS组和对照组在上述记录时间点耳鸣的改善情况,并比较taVNS组治疗前后的THI评分。①在taVNS治疗期间,93.65%的患者主观症状得到改善,28.6%的患者自愿接受第二个taVNS疗程治疗;②治疗10天时睡眠改善最佳,部分患者在3个月或6个月后睡眠状态较差;③taVNS组在治疗期间及治疗后焦虑得到改善,最佳效果时间为治疗后3个月和6个月;④两组THI评分无显著差异,但taVNS组在治疗后3个月和6个月有显著改善。taVNS治疗可显著改善耳鸣患者的睡眠障碍、焦虑障碍和耳鸣困扰,预防3个月和6个月后疗效良好。