Zeng Xiangli, Zheng Ke, Cen Jintian, Wu Shixin, Li Zhicheng, Yin Gendi, Ke Zhuoli, Wu Huiqing
Department of Otolaryngology,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,510630,China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb;35(2):105-108. doi: 10.13201/j.issn.2096-7993.2021.02.003.
The aim of this study is to investigate the efficacy of transcutaneous vagus nerve stimulation(taVNS) in the treatment of chronic tinnitus. taVNS was used to treat chronic decompensated tinnitus, 10 days as a course of treatment. Record and analyze the improvement of the patient's subjective symptoms during treatment. The THI, PSQI and DASS-21 scores were performed at 10 days, 3 months and 6 months after treatment. The improvement of tinnitus in taVNS group and control group at the above recorded time points was compared, and the THI score of taVNS group was compared before and after treatment. ① During the taVNS treatment, 93.65% of the patients achieved improvement in subjective symptoms, and 28.6% of the patients voluntarily accepted the second course of taVNS treatment; ② The sleep improvement was optimal when the treatment was 10 days, and some patients had poor sleep status after 3 or 6 months; ③ The anxiety of taVNS group was improved during and after treatment, and the best effect time was 3 months and 6 months after treatment; ④ There was no significant difference in THI score between the two groups, but there was significant improvement in taVNS group at 3 months and 6 months after treatment. taVNS treatment can significantly improve the sleep disorder, anxiety disorder and tinnitus disturbance of tinnitus patients, and the curative effect is good after 3 months and 6 months of prevention.
本研究旨在探讨经皮迷走神经刺激(taVNS)治疗慢性耳鸣的疗效。采用taVNS治疗慢性失代偿性耳鸣,10天为一个疗程。记录并分析治疗期间患者主观症状的改善情况。在治疗后10天、3个月和6个月进行耳鸣残疾指数(THI)、匹兹堡睡眠质量指数(PSQI)和抑郁焦虑压力量表-21(DASS-21)评分。比较taVNS组和对照组在上述记录时间点耳鸣的改善情况,并比较taVNS组治疗前后的THI评分。①在taVNS治疗期间,93.65%的患者主观症状得到改善,28.6%的患者自愿接受第二个taVNS疗程治疗;②治疗10天时睡眠改善最佳,部分患者在3个月或6个月后睡眠状态较差;③taVNS组在治疗期间及治疗后焦虑得到改善,最佳效果时间为治疗后3个月和6个月;④两组THI评分无显著差异,但taVNS组在治疗后3个月和6个月有显著改善。taVNS治疗可显著改善耳鸣患者的睡眠障碍、焦虑障碍和耳鸣困扰,预防3个月和6个月后疗效良好。